spectrin β II Antibody (F-7): sc-515592

spectrin β II Antibody (F-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects spectrin beta II protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-spectrin β II antibody (F-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. spectrin beta II protein plays a crucial role in maintaining the structural integrity of the cytoskeleton, particularly in non-erythroid cells, where spectrin beta II contributes to the organization and stabilization of the plasma membrane. spectrin beta II protein is essential for various cellular processes, including the regulation of membrane dynamics and the facilitation of intracellular transport. spectrin β II interacts with calmodulin in a calcium-dependent manner, highlighting spectrin β II′s importance in the calcium-mediated movement of the cytoskeleton at the membrane, which is vital for processes such as secretion and cell signaling. The human SPTBN1 gene encodes the nonerythroid form of β-spectrin, and SPTBN1′s proper function is critical for maintaining cellular architecture and facilitating communication between the cytoskeleton and the plasma membrane, making SPTBN1 a significant target for research in cell biology and related fields.

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spectrin β II Antibody (F-7) References:

1. α-Synuclein modulates neurite outgrowth by interacting with SPTBN1.  |  Lee, HJ., et al. 2012. Biochem Biophys Res Commun. 424: 497-502. PMID: 22771809
2. SPTBN1 suppresses the progression of epithelial ovarian cancer via SOCS3-mediated blockade of the JAK/STAT3 signaling pathway.  |  Chen, M., et al. 2020. Aging (Albany NY). 12: 10896-10911. PMID: 32516133
3. Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and Development.  |  Chen, S., et al. 2022. Cell Mol Gastroenterol Hepatol. 13: 949-973.e7. PMID: 34737104
4. β2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development.  |  Rao, S., et al. 2021. Sci Transl Med. 13: eabk2267. PMID: 34910547
5. SPTBN1 attenuates rheumatoid arthritis synovial cell proliferation, invasion, migration and inflammatory response by binding to PIK3R2.  |  Dai, LP., et al. 2022. Immun Inflamm Dis. 10: e724. PMID: 36444616
6. SPTBN1 abrogates renal clear cell carcinoma progression via glycolysis reprogramming in a GPT2-dependent manner.  |  Wu, J., et al. 2022. J Transl Med. 20: 603. PMID: 36527113
7. Clinical significance of nonerythrocytic spectrin Beta 1 (SPTBN1) in human kidney renal clear cell carcinoma and uveal melanoma: a study based on Pan-Cancer Analysis.  |  Tang, W., et al. 2023. BMC Cancer. 23: 303. PMID: 37013511
8. Interleukin-27-induced HIV-resistant dendritic cells suppress reveres transcription following virus entry in an SPTBN1, autophagy, and YB-1 independent manner.  |  Imamichi, T., et al. 2023. PLoS One. 18: e0287829. PMID: 37910521
9. Tumor cell SPTBN1 inhibits M2 polarization of macrophages by suppressing CXCL1 expression.  |  Wu, H., et al. 2024. J Cell Physiol. 239: 97-111. PMID: 37921259
10. SPTBN1 Mediates the Cytoplasmic Constraint of PTTG1, Impairing Its Oncogenic Activity in Human Seminoma.  |  Teveroni, E., et al. 2023. Int J Mol Sci. 24: PMID: 38069214

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-spectrin β II Antibody (F-7) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-spectrin β II Antibody (F-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

spectrin β II Antibody (F-7) Specifications

Alternate Product Name: spectrin β II

Product Clone Name: F-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2341-2363

Epitope Target: spectrin β II

Epitope Species: human

Product Reactivity/Detection: spectrin β II

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for spectrin β II Antibody (F-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred spectrin β II antibody is spectrin β II Antibody (42): sc-136074.