Date published: 2025-11-21

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SOCS-3 Antibody (SO1): sc-51699

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Datasheets
  • SOCS-3 Antibody (SO1) is a mouse monoclonal IgG2b, cited in 18 publications, provided at 100 µg/ml
  • raised against a purified full-length native SOC3 protein of human origin
  • recommended for detection of SOCS-3 of mouse, rat and human origin by WB, IP and ELISA
  • m-IgG2b BP-HRP is the preferred secondary detection reagent for SOCS-3 Antibody (SO1) for WB applications. This reagent is now offered in a bundle with SOCS-3 Antibody (SO1) (see ordering information below).

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SOCS-3 Antibody (SO1) is a mouse monoclonal IgG2b antibody that detects SOCS-3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SOCS-3 antibody (SO1) is available in a non-conjugated form, allowing for versatile experimental use. The suppressor of cytokine signaling 3 (SOCS-3) protein plays a crucial role in regulating cytokine signaling pathways, particularly in the negative feedback mechanism that modulates immune response. By inhibiting various cytokine signaling, including interleukin-6, SOCS-3 helps maintain homeostasis within the immune system and prevents excessive inflammation, which is vital for preventing autoimmune diseases and other inflammatory conditions. SOCS-3 structure features a central SH2 domain and a unique SOCS box, which are essential for interaction with phosphorylated tyrosine residues on target proteins, thereby facilitating regulatory functions. Understanding SOCS-3 dynamics and interactions is critical for developing therapeutic strategies aimed at modulating immune responses in various diseases.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

SOCS-3 Antibody (SO1)

sc-51699
100 µg/ml
$316.00

SOCS-3 Antibody (SO1): m-IgG2b BP-HRP Bundle

sc-548433
100 µg Ab; 10 µg BP
$354.00

Can we use this antibody for IF assay? If yes, what concentration do you suggest? If no, do you have SOCS3 antibodies for IF?

Asked by: as11
Thank you for your question. We have not yet tested this antibody for IF, or immunofluorescent staining, so this application is not recommended at this time. Unfortunately, we do not have any alternative antibodies against SOCS-3 that are recommended for IF at this time.
Answered by: Technical Support
Date published: 2017-07-27

For Western Blot, is it recommended to use denatured or non-denatured conditions with SOCS-3 (SO1): sc-51699 antibody?

Asked by: Dr Ninau Qelp
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 5 out of 5 by from good results in WBstrong and specific band in western blot wit mice liver lysates, dilution 1:1000
Date published: 2018-09-05
Rated 5 out of 5 by from 细胞免疫荧光刚试用了细胞免疫荧光,抗体说明书中没有表明可以用于此实验,但在293T细胞中试用结果很好,主要染色胞质。
Date published: 2017-10-26
Rated 5 out of 5 by from This antibody worked greatThis antibody worked great. I strongly recommend this antibody for detection of SOCS-3.
Date published: 2017-10-23
Rated 4 out of 5 by from Worked in WB using mouse/human cellsWorked in WB using mouse/human cells.
Date published: 2015-09-15
Rated 5 out of 5 by from WB: human and mouse cell lysatesWB: human and mouse cell lysates. -SCBT Publication Review
Date published: 2015-05-18
Rated 5 out of 5 by from Published western blot data using human bloodPublished western blot data using human blood samples. -SCBT Publication Review
Date published: 2015-04-03
Rated 5 out of 5 by from Nice band in WB using HeLa cell lysatesNice band in WB using HeLa cell lysates. -SCBT QC
Date published: 2015-01-21
Rated 4 out of 5 by from Positive western blot results in HeLaPositive western blot results in HeLa, IFN -treated HeLa, IL-6-treated HeLa and human PBL whole cell lysates. -SCBT QC
Date published: 2015-01-11
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SOCS-3 Antibody (SO1) is rated 4.8 out of 5 by 9.
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