SOCS-3 Antibody (6A463): sc-73045

SOCS-3 Antibody (6A463) is a mouse monoclonal IgG2b kappa light chain antibody that detects SOCS-3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SOCS-3 antibody (6A463) is available as a non-conjugated format. SOCS-3 protein plays a crucial role in the negative regulation of cytokine signaling, which is essential for maintaining immune homeostasis and preventing excessive inflammatory responses. SOCS-3 acts by inhibiting the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway, particularly in response to interleukin-6 (IL-6) and other cytokines. This regulation is vital because dysregulation of SOCS-3 can lead to various pathological conditions, including autoimmune diseases and cancer. SOCS-3 structure features a central SH2 domain and a unique carboxy-terminal SOCS box, which are critical for interaction with JAKs and other signaling molecules, thereby modulating the signaling cascade. SOCS-3 (6A463) antibody enables researchers to gain insights into the mechanisms of cytokine signaling and its implications in health and disease.

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SOCS-3 Antibody (6A463) References:

1. Angiotensin II (AngII) induces the expression of suppressor of cytokine signaling (SOCS)-3 in rat hypothalamus - a mechanism for desensitization of AngII signaling.  |  Torsoni, MA., et al. 2004. J Endocrinol. 181: 117-28. PMID: 15072572
2. Distinct activities of suppressor of cytokine signaling (SOCS) proteins and involvement of the SOCS box in controlling G-CSF signaling.  |  van de Geijn, GJ., et al. 2004. J Leukoc Biol. 76: 237-44. PMID: 15107455
3. SOCS-1 and SOCS-3 inhibit IL-4 and IL-13 induced activation of Eotaxin-3/CCL26 gene expression in HEK293 cells.  |  Hebenstreit, D., et al. 2005. Mol Immunol. 42: 295-303. PMID: 15589317
4. Activation of SOCS-3 by resistin.  |  Steppan, CM., et al. 2005. Mol Cell Biol. 25: 1569-75. PMID: 15684405
5. Unbiased identification of substrates for the Epac1-inducible E3 ubiquitin ligase component SOCS-3.  |  Williams, JJ. and Palmer, TM. 2012. Biochem Soc Trans. 40: 215-8. PMID: 22260693
6. Silencing of SOCS-1 and SOCS-3 suppresses renal interstitial fibrosis by alleviating renal tubular damage in a rat model of hydronephrosis.  |  Zheng, GH., et al. 2018. J Cell Biochem. 119: 2200-2211. PMID: 28857282
7. SOCS-3 contributes to bisphenol a exposure-induced insulin resistance in hepatocytes.  |  Qi, HM., et al. 2019. Sci China Life Sci. 62: 1597-1600. PMID: 31802416
8. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.  |  Yoshimura, A., et al. 1995. EMBO J. 14: 2816-26. PMID: 7796808
9. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation.  |  Matsumoto, A., et al. 1997. Blood. 89: 3148-54. PMID: 9129017
10. A family of cytokine-inducible inhibitors of signalling.  |  Starr, R., et al. 1997. Nature. 387: 917-21. PMID: 9202125
11. Twenty proteins containing a C-terminal SOCS box form five structural classes.  |  Hilton, DJ., et al. 1998. Proc Natl Acad Sci U S A. 95: 114-9. PMID: 9419338
12. The SOCS proteins: a new family of negative regulators of signal transduction.  |  Nicholson, SE. and Hilton, DJ. 1998. J Leukoc Biol. 63: 665-8. PMID: 9620657

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SOCS-3 Antibody (6A463) has 20 citations in a variety of scientific publications.

Primary antibodies like Anti-SOCS-3 Antibody (6A463) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SOCS-3 Antibody (6A463) Specifications

Alternate Product Name: SOCS-3

Product Clone Name: 6A463

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: SOCS-3

Epitope Species: human

Product Reactivity/Detection: SOCS-3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 20 citations in various scientific publications

Available Conjugates/Forms for SOCS-3 Antibody (6A463): N/A

The preferred SOCS-3 antibody is SOCS-3 Antibody (SO1): sc-51699.