SNM1B Antibody (B-7): sc-514300

SNM1B Antibody (B-7) is a mouse monoclonal IgG2a antibody that detects SNM1B in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SNM1B, also known as DCLRE1B or APOLLO, is a crucial 532 amino acid nuclear protein that plays a significant role in the repair of DNA interstrand cross-links (ICLs), which are detrimental to cellular integrity as SNM1B hinders DNA replication, segregation, and transcription. SNM1B′s importance lies not only in ICL repair but also in SNM1B′s interaction with TRF2, a protein essential for telomere maintenance and protection, particularly during the S-phase of the cell cycle. This interaction is vital for the early DNA-damage response, ensuring genomic stability. Additionally, SNM1B is a member of the DNA repair metallo-beta-lactamase family and undergoes post-translational modifications, including phosphorylation by ATM or ATR, which are critical for SNM1B′s activity and regulation. The gene encoding SNM1B is located on human chromosome 1, highlighting SNM1B′s evolutionary conservation and significance in maintaining cellular health.

The preferred SNM1B antibody is SNM1B Antibody (F-8): sc-374351.