SNF2L Antibody (H-3): sc-518199
- SNF2L Antibody (H-3) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 866-890 of SNF2L of human origin
- recommended for detection of SNF2L of human origin by WB, IP, IF and ELISA
- Anti-SNF2L Antibody (H-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SNF2L Antibody (H-3) for WB applications. These reagents are now offered in bundles with SNF2L Antibody (H-3) (see ordering information below).
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SEE ALSO...
SNF2L Antibody (H-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects SNF2L of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SNF2L Antibody (H-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SNF2L, also known as SMARCA1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1), is a crucial 1,054 amino acid protein that resides in the nucleus and plays a vital role in chromatin remodeling. SNF2L contains one helicase C-terminal domain, one helicase ATP-binding domain, and two SANT domains, which are essential for function in the nucleosome-remodeling factor (NURF) complex. This complex is responsible for ATP-dependent alteration of chromatin structure, facilitating access to DNA for transcription and repair processes. SNF2L plays a key role in brain development and neurite outgrowth, highlighting its significance in cellular differentiation and development. The gene encoding SNF2L is located on human chromosome X, which encompasses nearly 153 million base pairs and contains over 1,000 genes, underscoring the importance of this protein in various biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SNF2L Antibody (H-3) References:
- Cloning and characterization of the murine Imitation Switch (ISWI) genes: differential expression patterns suggest distinct developmental roles for Snf2h and Snf2l. | Lazzaro, MA. and Picketts, DJ. 2001. J Neurochem. 77: 1145-56. PMID: 11359880
- Cloning of human and bovine homologs of SNF2/SWI2: a global activator of transcription in yeast S. cerevisiae. | Okabe, I., et al. 1992. Nucleic Acids Res. 20: 4649-55. PMID: 1408766
- Isolation of human NURF: a regulator of Engrailed gene expression. | Barak, O., et al. 2003. EMBO J. 22: 6089-100. PMID: 14609955
- A tissue-specific, naturally occurring human SNF2L variant inactivates chromatin remodeling. | Barak, O., et al. 2004. J Biol Chem. 279: 45130-8. PMID: 15310751
- Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene. | Wang, F., et al. 2004. J Biol Chem. 279: 46733-41. PMID: 15347669
- CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L. | Banting, GS., et al. 2005. Hum Mol Genet. 14: 513-24. PMID: 15640247
- The imitation switch protein SNF2L regulates steroidogenic acute regulatory protein expression during terminal differentiation of ovarian granulosa cells. | Lazzaro, MA., et al. 2006. Mol Endocrinol. 20: 2406-17. PMID: 16740656
- Sp1 and CREB regulate basal transcription of the human SNF2L gene. | Xia, Y., et al. 2008. Biochem Biophys Res Commun. 368: 438-44. PMID: 18243132
- Characterization of novel isoforms and evaluation of SNF2L/SMARCA1 as a candidate gene for X-linked mental retardation in 12 families linked to Xq25-26. | Lazzaro, MA., et al. 2008. BMC Med Genet. 9: 11. PMID: 18302774
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SNF2L Antibody (H-3) | sc-518199 | 200 µg/ml | $322.00 | |||
SNF2L Antibody (H-3): m-IgG Fc BP-HRP Bundle | sc-551000 | 200 µg Ab; 10 µg BP | $361.00 | |||
SNF2L Antibody (H-3): m-IgGκ BP-HRP Bundle | sc-550999 | 200 µg Ab; 40 µg BP | $361.00 | |||
SNF2L Antibody (H-3): m-IgG1 BP-HRP Bundle | sc-551001 | 200 µg Ab; 20 µg BP | $361.00 | |||
SNF2L Antibody (H-3) AC | sc-518199 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SNF2L Antibody (H-3) HRP | sc-518199 HRP | 200 µg/ml | $322.00 | |||
SNF2L Antibody (H-3) FITC | sc-518199 FITC | 200 µg/ml | $336.00 | |||
SNF2L Antibody (H-3) PE | sc-518199 PE | 200 µg/ml | $349.00 | |||
SNF2L Antibody (H-3) Alexa Fluor® 488 | sc-518199 AF488 | 200 µg/ml | $364.00 | |||
SNF2L Antibody (H-3) Alexa Fluor® 546 | sc-518199 AF546 | 200 µg/ml | $364.00 | |||
SNF2L Antibody (H-3) Alexa Fluor® 594 | sc-518199 AF594 | 200 µg/ml | $364.00 | |||
SNF2L Antibody (H-3) Alexa Fluor® 647 | sc-518199 AF647 | 200 µg/ml | $364.00 | |||
SNF2L Antibody (H-3) Alexa Fluor® 680 | sc-518199 AF680 | 200 µg/ml | $364.00 | |||
SNF2L Antibody (H-3) Alexa Fluor® 790 | sc-518199 AF790 | 200 µg/ml | $364.00 |