SNAT2 Antibody (G-8): sc-166366

SNAT2 Antibody (G-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects SNAT2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SNAT2 (G-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SNAT2, also known as SLC38A2, plays a crucial role in the transport of neutral amino acids across cell membranes, which is vital for numerous physiological processes, including nutrient uptake, energy production, and neurotransmitter cycling. SNAT2 is predominantly expressed in the spinal cord and brain stem nuclei associated with the auditory system, highlighting SNAT2′s potential importance in neural function and development. SNAT2′s presence in placental tissue suggests involvement in fetal development, with disruptions in transport function linked to fetal growth retardation. Understanding SNAT2′s role in these contexts can provide insights into significance in both normal physiology and pathological conditions.

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SNAT2 Antibody (G-8) References:

1. Cloning and functional expression of ATA1, a subtype of amino acid transporter A, from human placenta.  |  Wang, H., et al. 2000. Biochem Biophys Res Commun. 273: 1175-9. PMID: 10891391
2. Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A.  |  Hatanaka, T., et al. 2000. Biochim Biophys Acta. 1467: 1-6. PMID: 10930503
3. Characterization of an N-system amino acid transporter expressed in retina and its involvement in glutamine transport.  |  Gu, S., et al. 2001. J Biol Chem. 276: 24137-44. PMID: 11325958
4. ATA2-mediated amino acid uptake following partial hepatectomy is regulated by redistribution to the plasma membrane.  |  Freeman, TL., et al. 2002. Arch Biochem Biophys. 400: 215-22. PMID: 12054432
5. Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element.  |  Palii, SS., et al. 2004. J Biol Chem. 279: 3463-71. PMID: 14623874
6. Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas.  |  Sidoryk, M., et al. 2004. Neuroreport. 15: 575-8. PMID: 15094455
7. Immunohistochemical localization of the amino acid transporter SNAT2 in the rat brain.  |  González-González, IM., et al. 2005. Neuroscience. 130: 61-73. PMID: 15561425
8. SNAT expression in rat placenta.  |  Novak, D., et al. 2006. Placenta. 27: 510-6. PMID: 16023720
9. SNAT2/SLC38A2 Confers the Stemness of Gastric Cancer Cells via Regulating Glutamine Level.  |  Nie, K. and Cai, M. 2022. Dig Dis Sci. 67: 2948-2956. PMID: 34173116
10. Placenta-specific Slc38a2/SNAT2 knockdown causes fetal growth restriction in mice.  |  Vaughan, OR., et al. 2021. Clin Sci (Lond). 135: 2049-2066. PMID: 34406367
11. The NERP-4-SNAT2 axis regulates pancreatic β-cell maintenance and function.  |  Zhang, W., et al. 2023. Nat Commun. 14: 8158. PMID: 38071217
12. UBE2C-induced crosstalk between mono- and polyubiquitination of SNAT2 promotes lymphatic metastasis in bladder cancer.  |  Li, W., et al. 2024. J Clin Invest. 134: PMID: 38949026

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SNAT2 Antibody (G-8) has 17 citations in a variety of scientific publications.

Primary antibodies like Anti-SNAT2 Antibody (G-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SNAT2 Antibody (G-8) Specifications

Alternate Product Name: SNAT2

Product Clone Name: G-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 21-39

Epitope Target: SNAT2

Epitope Species: human

Product Reactivity/Detection: SNAT2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 17 citations in various scientific publications

Available Conjugates/Forms for SNAT2 Antibody (G-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred SNAT2 antibody is SNAT2 Antibody (C-6): sc-514037.