SNAI 1 Antibody (G-7): sc-271977

SNAI1 Antibody (G-7) is a mouse monoclonal IgG1 kappa light chain antibody designed to recognize SNAI1, also known as Snail family transcriptional repressor 1 or SNAIL. SNAI1 monoclonal antibody (G-7) targets an epitope mapped between amino acids 113-139 within an internal region of the human SNAI1 protein, ensuring reliable detection across mouse, rat, and human species. SNAI1 is a crucial zinc-finger transcription factor that plays a significant role in regulating gene expression, particularly in processes such as epithelial-mesenchymal transition (EMT), which is essential for embryonic development, wound healing, and cancer metastasis. By repressing target genes, SNAI1 influences cell differentiation, migration, and survival, making SNAI1 a vital protein in both normal physiology and disease progression. Anti-SNAI1 antibody (G-7) is versatile and can be effectively used in various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA), providing researchers with a robust tool for studying SNAI1′s function and its implications in different biological contexts. Whether investigating developmental biology or exploring therapeutic targets in oncology, SNAI1 (G-7) antibody offers dependable performance and specificity without the need for high specificity claims.

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SNAI 1 Antibody (G-7) References:

1. Human transcription factor SLUG: mutation analysis in patients with neural tube defects and identification of a missense mutation (D119E) in the Slug subfamily-defining region.  |  Stegmann, K., et al. 1999. Mutat Res. 406: 63-9. PMID: 10479723
2. SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein.  |  Inukai, T., et al. 1999. Mol Cell. 4: 343-52. PMID: 10518215
3. Characterisation of the human snail (SNAI1) gene and exclusion as a major disease gene in craniosynostosis.  |  Twigg, SR. and Wilkie, AO. 1999. Hum Genet. 105: 320-6. PMID: 10543399
4. Genomic organization, expression, and chromosome location of the human SNAIL gene (SNAI1) and a related processed pseudogene (SNAI1P).  |  Paznekas, WA., et al. 1999. Genomics. 62: 42-9. PMID: 10585766
5. A novel snail-related transcription factor Smuc regulates basic helix-loop-helix transcription factor activities via specific E-box motifs.  |  Kataoka, H., et al. 2000. Nucleic Acids Res. 28: 626-33. PMID: 10606664
6. Cloning and developmental expression of Sna, a murine homologue of the Drosophila snail gene.  |  Nieto, MA., et al. 1992. Development. 116: 227-37. PMID: 1483390
7. Human SLUG gene organization, expression, and chromosome map location on 8q.  |  Cohen, ME., et al. 1998. Genomics. 51: 468-71. PMID: 9721220
8. Genomic organization, expression and chromosomal localization of the mouse Slug (Slugh) gene.  |  Jiang, R., et al. 1998. Biochim Biophys Acta. 1443: 251-4. PMID: 9838149

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SNAI 1 Antibody (G-7) has 129 citations in a variety of scientific publications.

Primary antibodies like Anti-SNAI 1 Antibody (G-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SNAI 1 Antibody (G-7) Specifications

Alternate Product Name: SNAI1

Product Clone Name: G-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 113-139

Epitope Target: SNAI 1

Epitope Species: human

Product Reactivity/Detection: SNAI 1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 129 citations in various scientific publications

Available Conjugates/Forms for SNAI 1 Antibody (G-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin, X: TransCruz Reagent

The preferred SNAI 1 antibody is SNAI 1 Antibody (E-10): sc-393172.