SMVT Antibody (C-9): sc-514319

SMVT Antibody (C-9) is a mouse monoclonal IgG2b antibody that detects sodium-dependent multivitamin transporter (SMVT) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SMVT antibody (C-9) recognizes a 635 amino acid protein that is a member of the sodium-coupled glucose transporter family, characterized by its 12 putative transmembrane domains with both the N and C termini oriented towards the cytoplasm. The primary function of SMVT is to facilitate the transport of essential vitamins, including pantothenate, biotin, and the metabolite lipoate, into various human tissues, which is crucial for numerous metabolic processes. Biotin, also known as vitamin B6, plays a vital role in synthesizing fatty acids, gluconeogenesis, and the metabolism of leucine, while pantothenate, or vitamin B5, is essential for the metabolism and synthesis of carbohydrates, proteins, and fats. Lipoate is integral to oxidative metabolism, underscoring the importance of SMVT in maintaining cellular health and energy production. The transport mechanism employed by SMVT is a specialized carrier-mediated system that relies on the transmembrane sodium ion gradient and membrane potential, making this an active process that requires energy. SMVT monoclonal antibody (C-9) effectively detects this critical protein in various applications, making this reagent an invaluable tool for researchers studying vitamin transport and metabolism.

The preferred SMVT antibody is SMVT Antibody (D-11): sc-390080.