SMVT Antibody (D-11): sc-390080

SMVT Antibody (D-11) is a mouse monoclonal IgM kappa antibody that detects the SMVT protein of human origin, Slc5a6 protein of mouse origin, and the corresponding rat homolog by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SMVT antibody (D-11) is available as the non-conjugated form. The sodium-dependent multivitamin transporter (SMVT) is a 635 amino acid protein that plays a crucial role in the transport of essential vitamins such as pantothenate, biotin, and the metabolite lipoate into various human tissues. Located in the plasma membrane, SMVT is vital for cellular uptake of these nutrients, which are necessary for numerous metabolic processes. Biotin, also known as vitamin B7, is essential for synthesizing fatty acids, gluconeogenesis, and metabolizing amino acids, while pantothenate, or vitamin B5, is critical for the metabolism and synthesis of carbohydrates, proteins, and fats. Lipoate, on the other hand, is involved in oxidative metabolism, making SMVT indispensable for maintaining cellular health and energy production. The protein′s structure includes 12 putative transmembrane domains, with both the N and C termini oriented towards the cytoplasm, facilitating its function as a specialized carrier that utilizes the transmembrane sodium ion gradient and membrane potential to actively transport these vital nutrients into cells.

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SMVT Antibody (D-11) References:

1. Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization.  |  Wang, H., et al. 1999. J Biol Chem. 274: 14875-83. PMID: 10329687
2. Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter.  |  Prasad, PD., et al. 1999. Arch Biochem Biophys. 366: 95-106. PMID: 10334869
3. Structure and function of mammalian sodium-dependent multivitamin transporter.  |  Prasad, PD. and Ganapathy, V. 2000. Curr Opin Clin Nutr Metab Care. 3: 263-6. PMID: 10929671
4. Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system.  |  Balamurugan, K., et al. 2003. Am J Physiol Gastrointest Liver Physiol. 285: G73-7. PMID: 12646417
5. Biotin supply affects rates of cell proliferation, biotinylation of carboxylases and histones, and expression of the gene encoding the sodium-dependent multivitamin transporter in JAr choriocarcinoma cells.  |  Crisp, SE., et al. 2004. Eur J Nutr. 43: 23-31. PMID: 14991266
6. Biotin availability regulates expression of the sodium-dependent multivitamin transporter and the rate of biotin uptake in HepG2 cells.  |  Pacheco-Alvarez, D., et al. 2005. Mol Genet Metab. 85: 301-7. PMID: 15905112
7. Biotin uptake and cellular translocation in human derived retinoblastoma cell line (Y-79): a role of hSMVT system.  |  Kansara, V., et al. 2006. Int J Pharm. 312: 43-52. PMID: 16459033
8. Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate.  |  Prasad, PD., et al. 1998. J Biol Chem. 273: 7501-6. PMID: 9516450

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SMVT Antibody (D-11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-SMVT Antibody (D-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SMVT Antibody (D-11) Specifications

Alternate Product Name: SMVT

Product Clone Name: D-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 571-607

Epitope Target: SMVT

Epitope Species: human

Product Reactivity/Detection: SMVT of human origin, Slc5a6 of mouse origin, and the corresponding rat homolog

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for SMVT Antibody (D-11): P: Blocking Peptide