SMS1 Antibody (E-5): sc-166436

SMS1 Antibody (E-5) is a mouse monoclonal IgG2a antibody that detects sphingomyelin synthase 1 (SMS1) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SMS1 plays a crucial role in lipid metabolism by catalyzing the conversion of phosphatidylcholine and ceramide into sphingomyelin and diacylglycerol, which are essential components of cellular membranes. Proper functioning of SMS1 is vital for maintaining cellular homeostasis, as SMS1 influences both cell survival and apoptosis, making SMS1 a significant player in various physiological and pathological processes. Located primarily in the Golgi apparatus, SMS1′s activity is tightly regulated by substrate concentrations, which can shift the balance between cell death and survival pathways. SMS1 is expressed in several tissues, including liver, muscle, heart, brain, stomach, and kidney, and exists in multiple isoforms due to alternative splicing, each with distinct tissue distribution and functional roles. Anti-SMS1 antibody (E-5) is an invaluable tool for researchers studying sphingolipid metabolism mechanisms and implications in diseases such as cancer, where SMS activity can be modulated by agents like tricyclodecan-9-yl-xanthogenate, highlighting SMS1′s potential as a therapeutic target.

The preferred SMS1 antibody is SMS1 Antibody (G-8): sc-133135.