SmarcAL1 Antibody (A-2): sc-376377
- SmarcAL1 Antibody (A-2) is a mouse monoclonal IgG1 κ SmarcAL1 antibody, cited in 32 publications, provided at 200 µg/ml
- raised against amino acids 831-954 mapping at the C-terminus of SmarcAL1 of human origin
- SmarcAL1 Antibody (A-2) is recommended for detection of SmarcAL1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-SmarcAL1 Antibody (A-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SmarcAL1 Antibody (A-2) for WB and IHC(P) applications. These reagents are now offered in bundles with SmarcAL1 Antibody (A-2) (see ordering information below).
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SmarcAL1 Antibody (A-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects SmarcAL1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). SmarcAL1 (A-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SmarcAL1, also known as SWI/SNF-related matrix-associated Actin-dependent regulator of chromatin subfamily A-like protein 1, is a 954 amino acid member of the SWI/SNF family of helicase and ATPase proteins, primarily localized in the nucleus. SmarcAL1 plays a crucial role in ATP-dependent nucleosome remodeling, which is essential for regulating gene expression and maintaining chromatin structure. SmarcAL1 contains a conserved C-terminal SNF2 domain, a helicase ATP-binding domain, and two HARP domains, all of which are vital for chromatin dynamics. Defects in the gene encoding SmarcAL1 are linked to Schimke immuno-osseous dysplasia (SIOD), an autosomal recessive disorder characterized by renal dysfunction, spondyloepiphyseal dysplasia, and T cell immunodeficiency, highlighting SmarcAL1′s significance in human health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SmarcAL1 Antibody (A-2) References:
- Mutant chromatin remodeling protein SMARCAL1 causes Schimke immuno-osseous dysplasia. | Boerkoel, CF., et al. 2002. Nat Genet. 30: 215-20. PMID: 11799392
- Longevity in Schimke immuno-osseous dysplasia. | Lou, S., et al. 2002. J Med Genet. 39: 922-5. PMID: 12471207
- Schimke-immuno-osseous dysplasia: new mutation with weak genotype-phenotype correlation in siblings. | Lücke, T., et al. 2005. Am J Med Genet A. 135: 202-5. PMID: 15880370
- Association of migraine-like headaches with Schimke immuno-osseous dysplasia. | Kilic, SS., et al. 2005. Am J Med Genet A. 135: 206-10. PMID: 15884045
- R561C missense mutation in the SMARCAL1 gene associated with mild Schimke immuno-osseous dysplasia. | Bökenkamp, A., et al. 2005. Pediatr Nephrol. 20: 1724-8. PMID: 16237566
- Schimke immuno-osseous dysplasia: a cell autonomous disorder? | Elizondo, LI., et al. 2006. Am J Med Genet A. 140: 340-8. PMID: 16419127
- Schimke immunoosseous dysplasia: suggestions of genetic diversity. | Clewing, JM., et al. 2007. Hum Mutat. 28: 273-83. PMID: 17089404
- A basic peptide derived from the HARP C-terminus inhibits anchorage-independent growth of DU145 prostate cancer cells. | Bermek, O., et al. 2007. Exp Cell Res. 313: 4041-50. PMID: 17727841
- Cloning and characterization of HARP/SMARCAL1: a prokaryotic HepA-related SNF2 helicase protein from human and mouse. | Coleman, MA., et al. 2000. Genomics. 65: 274-82. PMID: 10857751
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SmarcAL1 Antibody (A-2) | sc-376377 | 200 µg/ml | $322.00 | |||
SmarcAL1 Antibody (A-2): m-IgG Fc BP-HRP Bundle | sc-529863 | 200 µg Ab; 10 µg BP | $361.00 | |||
SmarcAL1 Antibody (A-2): m-IgGκ BP-HRP Bundle | sc-522935 | 200 µg Ab, 40 µg BP | $361.00 | |||
SmarcAL1 Antibody (A-2): m-IgG1 BP-HRP Bundle | sc-543732 | 200 µg Ab; 20 µg BP | $361.00 | |||
SmarcAL1 Antibody (A-2) AC | sc-376377 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SmarcAL1 Antibody (A-2) HRP | sc-376377 HRP | 200 µg/ml | $322.00 | |||
SmarcAL1 Antibody (A-2) FITC | sc-376377 FITC | 200 µg/ml | $336.00 | |||
SmarcAL1 Antibody (A-2) PE | sc-376377 PE | 200 µg/ml | $349.00 | |||
SmarcAL1 Antibody (A-2) Alexa Fluor® 488 | sc-376377 AF488 | 200 µg/ml | $364.00 | |||
SmarcAL1 Antibody (A-2) Alexa Fluor® 546 | sc-376377 AF546 | 200 µg/ml | $364.00 | |||
SmarcAL1 Antibody (A-2) Alexa Fluor® 594 | sc-376377 AF594 | 200 µg/ml | $364.00 | |||
SmarcAL1 Antibody (A-2) Alexa Fluor® 647 | sc-376377 AF647 | 200 µg/ml | $364.00 | |||
SmarcAL1 Antibody (A-2) Alexa Fluor® 680 | sc-376377 AF680 | 200 µg/ml | $364.00 | |||
SmarcAL1 Antibody (A-2) Alexa Fluor® 790 | sc-376377 AF790 | 200 µg/ml | $364.00 |