SHBG Antibody (G-4): sc-377031

SHBG Antibody (G-4) is a mouse monoclonal IgG1 antibody that detects sex hormone-binding globulin (SHBG) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SHBG is a secreted homodimer that plays a crucial role in the transport and regulation of steroid hormones, specifically binding to 7-β-estradiol, 5-α-dihydrotestosterone, and testosterone. By modulating the plasma concentration of these hormones, SHBG is essential for maintaining hormonal balance and influencing various physiological processes, including reproductive functions and metabolic clearance rates. SHBG is primarily synthesized in the liver and testis, with Sertoli cells in the testis being responsible for production. Once synthesized, SHBG is secreted into the seminiferous tubule and subsequently transported to the epididymis, where SHBG facilitates the transport of androgens. The ability of SHBG to bind and transport these hormones underscores its importance in endocrine regulation and highlights its potential as a biomarker for various hormonal disorders. Anti-SHBG antibody (G-4) is an invaluable tool for researchers studying the intricate roles of steroid hormones in human health and disease.

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SHBG Antibody (G-4) References:

1. Sex Hormone-Binding Globulin (SHBG), estradiol and breast cancer.  |  Fortunati, N., et al. 2010. Mol Cell Endocrinol. 316: 86-92. PMID: 19770023
2. Association between sex hormone-binding globulin (SHBG) and metabolic syndrome among men.  |  Sá, EQ., et al. 2014. Sao Paulo Med J. 132: 111-5. PMID: 24714992
3. Sex Hormone Binding Globulin (SHBG) as a Marker of Clinical Disorders.  |  Goldštajn, MŠ., et al. 2016. Coll Antropol. 40: 211-8. PMID: 29139641
4. Sex Hormone-Binding Globulin (SHBG) as an Early Biomarker and Therapeutic Target in Polycystic Ovary Syndrome.  |  Qu, X. and Donnelly, R. 2020. Int J Mol Sci. 21: PMID: 33139661
5. Sex Hormone Binding Globulin (SHBG) Mitigates ER Stress in Hepatocytes In Vitro and Ex Vivo.  |  Kornicka-Garbowska, K., et al. 2021. Cells. 10: PMID: 33808055
6. Sex Hormone-Binding Globulin (SHBG) Maintains Proper Equine Adipose-Derived Stromal Cells (ASCs)' Metabolic Functions and Negatively Regulates their Basal Adipogenic Potential.  |  Bourebaba, L., et al. 2023. Stem Cell Rev Rep. 19: 2251-2273. PMID: 37402098
7. Sex hormone-binding globulin (SHBG) mitigates ER stress and improves viability and insulin sensitivity in adipose-derived mesenchymal stem cells (ASC) of equine metabolic syndrome (EMS)-affected horses.  |  Bourebaba, N., et al. 2023. Cell Commun Signal. 21: 230. PMID: 37697311
8. Longitudinal Changes in Sex Hormone Binding Globulin (SHBG) and Risk of Incident Diabetes: The Study of Women's Health Across the Nation (SWAN).  |  Hedderson, MM., et al. 2024. Diabetes Care. 47: 676-682. PMID: 38320264
9. Sex hormone binding globulin (SHBG) serum levels and insulin resistance in men on chronic hemodialysis.  |  Nikolaou, E., et al. 2024. Diabetol Metab Syndr. 16: 166. PMID: 39014506
10. Interrelations between sex hormone-binding globulin (SHBG), plasma lipoproteins and cardiovascular risk.  |  Pugeat, M., et al. 1995. J Steroid Biochem Mol Biol. 53: 567-72. PMID: 7626511

The preferred SHBG antibody is SHBG Antibody (C-2): sc-377032.