SH2D4A Antibody (F-5): sc-514170

SH2D4A Antibody (F-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects SH2D4A of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SH2D4A (F-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SH2D4A, also known as SH2A, is a 454 amino acid docking protein that is widely expressed and belongs to the SH2 signaling protein family, which plays a crucial role in intracellular signaling pathways. Localized primarily in the cytoplasm, SH2D4A contains a single Src homology 2 (SH2) domain that specifically binds to tyrosine-phosphorylated regions of target proteins, thereby linking activated growth factors to downstream signaling molecules. This interaction is vital for the regulation of cellular signal transduction, and SH2D4A is thought to act as an inhibitory factor in protein kinase C signaling pathways. Notably, aberrant expression of SH2D4A has been observed in various cancers, suggesting potential involvement in tumorigenesis and making SH2D4A a significant target for cancer research.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SH2D4A Antibody (F-5) References:

1. [A novel member of SH(2) signaling protein family: cloning and characterization of SH(2)A gene].  |  Dai, S., et al. 2002. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 19: 458-62. PMID: 12476414
2. [Effect of SH2A gene in cell signal transduction and its subcellular locolization].  |  Ding, Q., et al. 2003. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 20: 499-503. PMID: 14669218
3. Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik.  |  Patrakka, J., et al. 2007. J Am Soc Nephrol. 18: 689-97. PMID: 17251388
4. SH2 domain-based tyrosine phosphorylation array.  |  Jiang, X., et al. 2008. Methods Mol Biol. 441: 153-61. PMID: 18370317

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SH2D4A Antibody (F-5) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-SH2D4A Antibody (F-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SH2D4A Antibody (F-5) Specifications

Alternate Product Name: SH2D4A

Product Clone Name: F-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 113-165

Epitope Target: SH2D4A

Epitope Species: human

Product Reactivity/Detection: SH2D4A

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for SH2D4A Antibody (F-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin