SCO1 Antibody (B-9): sc-365380
- SCO1 Antibody (B-9) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 178-243 mapping near the C-terminus of SCO1 of human origin
- recommended for detection of SCO1 of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SCO1 Antibody (B-9). This work is in progress.
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SCO1 Antibody (B-9) is a mouse monoclonal IgG2b antibody that detects SCO1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SCO1 is a vital inner membrane protein located in the mitochondrion, playing a crucial role in the insertion and transport of copper to the active site of cytochrome c oxidase (COX), which is essential for energy production as it serves as the terminal enzyme in the respiratory chain. The proper functioning of SCO1 is particularly important in tissues with high oxidative phosphorylation demands, such as the brain, heart, and muscle, where SCO1 is predominantly expressed. Deficiencies in the SCO1 gene can lead to cytochrome c oxidase deficiency, a heterogeneous disorder that disrupts cellular energy metabolism. Additionally, SCO1′s interaction with other proteins involved in mitochondrial function underscores SCO1′s significance in maintaining cellular health and energy balance. Anti-SCO1 antibody (B-9) is an invaluable tool for researchers studying mitochondrial function and related disorders, providing insights into the molecular mechanisms underlying energy production and its associated pathologies.
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SCO1 Antibody (B-9) References:
- Human members of the SCO1 gene family: complementation analysis in yeast and intracellular localization. | Paret, C., et al. 1999. FEBS Lett. 447: 65-70. PMID: 10218584
- Characterization of human SCO1 and COX17 genes in mitochondrial cytochrome-c-oxidase deficiency. | Horvath, R., et al. 2000. Biochem Biophys Res Commun. 276: 530-3. PMID: 11027508
- Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase. | Leary, SC., et al. 2004. Hum Mol Genet. 13: 1839-48. PMID: 15229189
- Human Sco1 and Sco2 function as copper-binding proteins. | Horng, YC., et al. 2005. J Biol Chem. 280: 34113-22. PMID: 16091356
- The P174L mutation in human Sco1 severely compromises Cox17-dependent metallation but does not impair copper binding. | Cobine, PA., et al. 2006. J Biol Chem. 281: 12270-6. PMID: 16520371
- Human Sco1 functional studies and pathological implications of the P174L mutant. | Banci, L., et al. 2007. Proc Natl Acad Sci U S A. 104: 15-20. PMID: 17182746
- The human cytochrome c oxidase assembly factors SCO1 and SCO2 have regulatory roles in the maintenance of cellular copper homeostasis. | Leary, SC., et al. 2007. Cell Metab. 5: 9-20. PMID: 17189203
- Unexpected vascular enrichment of SCO1 over SCO2 in mammalian tissues: implications for human mitochondrial disease. | Brosel, S., et al. 2010. Am J Pathol. 177: 2541-8. PMID: 20864674
- Copper metabolism in cell death and autophagy. | Xue, Q., et al. 2023. Autophagy. 19: 2175-2195. PMID: 37055935
- Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain. | Petruzzella, V., et al. 1998. Genomics. 54: 494-504. PMID: 9878253
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SCO1 Antibody (B-9) | sc-365380 | 200 µg/ml | $322.00 |