SCML2 Antibody (H-3): sc-393265
- SCML2 Antibody (H-3) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 551-592 within an internal region of SCML2 of human origin
- recommended for detection of SCML2 isoforms 1 and 2 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SCML2 Antibody (H-3) for WB applications. These reagents are now offered in bundles with SCML2 Antibody (H-3) (see ordering information below).
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SCML2 Antibody (H-3) is a mouse monoclonal IgG2a antibody that detects SCML2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SCML2, a human homolog of the Drosophila Polycomb protein SCM, plays a crucial role in transcriptional repression and is part of the Polycomb group (PcG) gene family, which is essential for regulating gene expression during embryonic development. SCML2 is predominantly expressed in the placenta, testis, and thymus, highlighting its significance in reproductive and immune functions. Notably, SCML2 undergoes post-translational modifications, including phosphorylation by ATR or ATM in response to DNA damage, which may influence activity and stability. Additionally, alternative splicing of SCML2 results in two isoforms, allowing for functional diversity that may be critical in various biological contexts. SCML2′s interaction with other proteins within the PcG complex underscores its importance in maintaining cellular identity and regulating developmental processes, making anti-SCML2 antibody (H-3) an invaluable tool for researchers studying gene regulation and chromatin dynamics.
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SCML2 Antibody (H-3) References:
- Adaptive evolution of SCML1 in primates, a gene involved in male reproduction. | Wu, HH. and Su, B. 2008. BMC Evol Biol. 8: 192. PMID: 18601738
- Identification of molecular biomarkers for pancreatic cancer with mRMR shortest path method. | Shen, S., et al. 2017. Oncotarget. 8: 41432-41439. PMID: 28611293
- Dynamic reorganization of open chromatin underlies diverse transcriptomes during spermatogenesis. | Maezawa, S., et al. 2018. Nucleic Acids Res. 46: 593-608. PMID: 29126117
- A Neofunctionalized X-Linked Ampliconic Gene Family Is Essential for Male Fertility and Equal Sex Ratio in Mice. | Kruger, AN., et al. 2019. Curr Biol. 29: 3699-3706.e5. PMID: 31630956
- Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition. | Maezawa, S., et al. 2020. Nat Struct Mol Biol. 27: 978-988. PMID: 32895557
- Analysis of protein-DNA interactions in chromatin by UV induced cross-linking and mass spectrometry. | Stützer, A., et al. 2020. Nat Commun. 11: 5250. PMID: 33067435
- Construction of AP003469.4-miRNAs-mRNAs ceRNA network to reveal potential biomarkers for hepatocellular carcinoma. | Fan, T., et al. 2022. Am J Cancer Res. 12: 1484-1501. PMID: 35530270
- Whole exome sequencing analysis of 167 men with primary infertility. | Zhou, H., et al. 2024. BMC Med Genomics. 17: 230. PMID: 39267058
- METTL16 is Required for Meiotic Sex Chromosome Inactivation and DSB Formation and Recombination during Male Meiosis. | Yin, L., et al. 2025. Adv Sci (Weinh). 12: e2406332. PMID: 39607422
- CTCF-mediated 3D chromatin sets up the gene expression program in the male germline. | Kitamura, Y., et al. 2025. Nat Struct Mol Biol.. PMID: 40033153
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SCML2 Antibody (H-3) | sc-393265 | 200 µg/ml | $322.00 | |||
SCML2 Antibody (H-3): m-IgG Fc BP-HRP Bundle | sc-538176 | 200 µg Ab; 10 µg BP | $361.00 | |||
SCML2 Antibody (H-3): m-IgGκ BP-HRP Bundle | sc-535738 | 200 µg Ab; 40 µg BP | $361.00 | |||
SCML2 (H-3) Neutralizing Peptide | sc-393265 P | 100 µg/0.5 ml | $69.00 |