SCML2 Antibody (C-7): sc-398400
- SCML2 Antibody (C-7) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 630-651 near the C-terminus of SCML2 of human origin
- recommended for detection of SCML2 isoforms 1 and 2 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SCML2 Antibody (C-7) for WB applications. These reagents are now offered in bundles with SCML2 Antibody (C-7) (see ordering information below).
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SCML2 Antibody (C-7) is a mouse monoclonal IgG2a antibody that detects SCML2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SCML2, a human homolog of the Drosophila Polycomb protein, plays a crucial role in transcriptional repression and is essential for regulating gene expression during development. SCML2 is predominantly expressed in the placenta, testis, and thymus, highlighting its importance in reproductive and immune functions. Notably, SCML2 undergoes post-translational modifications, including phosphorylation by ATR or ATM in response to DNA damage, which can influence activity and stability. Alternative splicing of SCML2 results in two isoforms, allowing for functional diversity that may be critical in various biological contexts. Anti-SCML2 antibody (C-7) is an invaluable tool for researchers studying gene regulation, cellular responses to DNA damage, and the intricate mechanisms of development in human tissues.
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SCML2 Antibody (C-7) References:
- Identification of SCML2, a second human gene homologous to the Drosophila sex comb on midleg (Scm): A new gene cluster on Xp22. | Montini, E., et al. 1999. Genomics. 58: 65-72. PMID: 10331946
- The malignant brain tumor repeats of human SCML2 bind to peptides containing monomethylated lysine. | Santiveri, CM., et al. 2008. J Mol Biol. 382: 1107-12. PMID: 18706910
- Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes. | Lecona, E., et al. 2013. PLoS Biol. 11: e1001737. PMID: 24358021
- Solution NMR structure of the DNA-binding domain from Scml2 (sex comb on midleg-like 2). | Bezsonova, I. 2014. J Biol Chem. 289: 15739-49. PMID: 24727478
- USP7 cooperates with SCML2 to regulate the activity of PRC1. | Lecona, E., et al. 2015. Mol Cell Biol. 35: 1157-68. PMID: 25605328
- SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination. | Hasegawa, K., et al. 2015. Dev Cell. 32: 574-88. PMID: 25703348
- Polycomb protein SCML2 facilitates H3K27me3 to establish bivalent domains in the male germline. | Maezawa, S., et al. 2018. Proc Natl Acad Sci U S A. 115: 4957-4962. PMID: 29686098
- SCML2 promotes heterochromatin organization in late spermatogenesis. | Maezawa, S., et al. 2018. J Cell Sci. 131: PMID: 30097555
- A rapidly evolved domain, the SCML2 DNA-binding repeats, contributes to chromatin binding of mouse SCML2†. | Maezawa, S., et al. 2019. Biol Reprod. 100: 409-419. PMID: 30137219
- Discordant interactions between YAP1 and polycomb group protein SCML2 determine cell fate. | Boston, AM., et al. 2023. iScience. 26: 107964. PMID: 37810219
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SCML2 Antibody (C-7) | sc-398400 | 200 µg/ml | $316.00 | |||
SCML2 Antibody (C-7): m-IgG Fc BP-HRP Bundle | sc-538435 | 200 µg Ab; 10 µg BP | $354.00 | |||
SCML2 Antibody (C-7): m-IgGκ BP-HRP Bundle | sc-536048 | 200 µg Ab; 40 µg BP | $354.00 | |||
SCML2 Antibody (C-7): m-IgG2a BP-HRP Bundle | sc-548301 | 200 µg Ab; 10 µg BP | $354.00 | |||
SCML2 (C-7) Neutralizing Peptide | sc-398400 P | 100 µg/0.5 ml | $68.00 |