SCD1 Antibody (E-8): sc-515844

SCD1 Antibody (E-8) is a mouse monoclonal IgM antibody that detects SCD1 in mouse samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SCD1 (E-8) antibody is available in a non-conjugated form, allowing for versatile experimental use. Stearoyl-CoA desaturase (SCD) is a crucial microsomal enzyme that catalyzes the conversion of saturated fatty acids into monounsaturated fatty acids, specifically oleate and palmitoleate, which are essential components of membrane phospholipids, triglycerides, and cholesterol esters. SCD function is vital for maintaining cellular lipid homeostasis and membrane fluidity, playing a significant role in triacylglycerol and phospholipid secretion. SCD is involved in regulating cellular cholesterol levels, making SCD a key player in metabolic processes. SCD undergoes rapid turnover, providing a valuable model for studying selective degradation of short-lived proteins within the endoplasmic reticulum. SCD expression increases in cells differentiating into adipocytes and various tumor cell lines, highlighting SCD importance in both normal physiology and disease states. The SCD gene family exhibits variability in gene number across different species due to gene duplication events, and SCD expression is influenced by dietary levels of unsaturated fatty acids, underscoring the intricate relationship between nutrition and metabolic regulation.

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SCD1 Antibody (E-8) References:

1. The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1.  |  Miyazaki, M., et al. 2000. J Biol Chem. 275: 30132-8. PMID: 10899171
2. The N terminus of microsomal delta 9 stearoyl-CoA desaturase contains the sequence determinant for its rapid degradation.  |  Mziaut, H., et al. 2000. Proc Natl Acad Sci U S A. 97: 8883-8. PMID: 10922050
3. Stearoyl-CoA desaturase 1 coding sequences and antisense RNA affect lipid secretion in transfected chicken LMH hepatoma cells.  |  Diot, C., et al. 2000. Arch Biochem Biophys. 380: 243-50. PMID: 10933878
4. Differential regulation of the stearoyl-CoA desaturase genes by thiazolidinediones in 3T3-L1 adipocytes.  |  Kim, YC., et al. 2000. J Lipid Res. 41: 1310-6. PMID: 10946019
5. Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase.  |  Kaestner, KH., et al. 1989. J Biol Chem. 264: 14755-61. PMID: 2570068
6. Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase.  |  Ntambi, JM., et al. 1988. J Biol Chem. 263: 17291-300. PMID: 2903162
7. Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway.  |  Zhu, X., et al. 2019. Free Radic Biol Med. 141: 192-204. PMID: 31226399
8. FBW7-NRA41-SCD1 axis synchronously regulates apoptosis and ferroptosis in pancreatic cancer cells.  |  Ye, Z., et al. 2021. Redox Biol. 38: 101807. PMID: 33271455
9. SCD1/FADS2 fatty acid desaturases equipoise lipid metabolic activity and redox-driven ferroptosis in ascites-derived ovarian cancer cells.  |  Xuan, Y., et al. 2022. Theranostics. 12: 3534-3552. PMID: 35547771
10. Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutant colorectal cancer.  |  Chen, H., et al. 2022. Redox Biol. 55: 102426. PMID: 35963119
11. ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer.  |  Wong, TL., et al. 2023. Nat Commun. 14: 2861. PMID: 37208334
12. Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues.  |  Li, J., et al. 1994. Int J Cancer. 57: 348-52. PMID: 7909540

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SCD1 Antibody (E-8) has 18 citations in a variety of scientific publications.

Primary antibodies like Anti-SCD1 Antibody (E-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SCD1 Antibody (E-8) Specifications

Alternate Product Name: SCD1

Product Clone Name: E-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 34-57

Epitope Target: SCD1

Epitope Species: mouse

Product Reactivity/Detection: SCD1 and SCD3

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 18 citations in various scientific publications

Available Conjugates/Forms for SCD1 Antibody (E-8): N/A

The preferred SCD antibody is SCD Antibody (CD.E10): sc-58420.