SCD Antibody (CD.E10): sc-58420

SCD Antibody (CD.E10) is a mouse monoclonal IgG2b antibody that detects stearoyl-CoA desaturase (SCD) in human, mouse, and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SCD antibody (CD.E10) is available in a non-conjugated form, providing flexibility for various experimental setups. Stearoyl-CoA desaturase is a crucial microsomal enzyme involved in the synthesis of oleate and palmitoleate, which are essential monounsaturated fatty acids that contribute to the composition of membrane phospholipids, triglycerides, and cholesterol esters. SCD (CD.E10) monoclonal antibody recognizes a protein vital for maintaining cellular lipid homeostasis, as SCD plays a significant role in the secretion of triacylglycerols and phospholipids, as well as in regulating cellular cholesterol levels. Notably, SCD undergoes rapid turnover within the cell, making SCD an excellent model for studying the selective degradation of short-lived endoplasmic reticulum proteins. Additionally, SCD functions as a key regulator of membrane fluidity, which is critical for various cellular processes, including signal transduction and membrane fusion. Increased expression of SCD has been observed in differentiating adipocytes and certain tumor cell lines, highlighting SCD′s importance in metabolic regulation and cancer biology. The SCD gene family exhibits variability in gene number across species due to gene duplication events, and SCD expression is influenced by dietary levels of unsaturated fatty acids, further emphasizing SCD′s role in metabolic adaptation.

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SCD Antibody (CD.E10) References:

1. The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1.  |  Miyazaki, M., et al. 2000. J Biol Chem. 275: 30132-8. PMID: 10899171
2. The N terminus of microsomal delta 9 stearoyl-CoA desaturase contains the sequence determinant for its rapid degradation.  |  Mziaut, H., et al. 2000. Proc Natl Acad Sci U S A. 97: 8883-8. PMID: 10922050
3. Stearoyl-CoA desaturase 1 coding sequences and antisense RNA affect lipid secretion in transfected chicken LMH hepatoma cells.  |  Diot, C., et al. 2000. Arch Biochem Biophys. 380: 243-50. PMID: 10933878
4. Differential regulation of the stearoyl-CoA desaturase genes by thiazolidinediones in 3T3-L1 adipocytes.  |  Kim, YC., et al. 2000. J Lipid Res. 41: 1310-6. PMID: 10946019
5. Stearoyl CoA desaturase (SCD) facilitates proliferation of prostate cancer cells through enhancement of androgen receptor transactivation.  |  Kim, SJ., et al. 2011. Mol Cells. 31: 371-7. PMID: 21331774
6. Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase.  |  Kaestner, KH., et al. 1989. J Biol Chem. 264: 14755-61. PMID: 2570068
7. Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase.  |  Ntambi, JM., et al. 1988. J Biol Chem. 263: 17291-300. PMID: 2903162
8. Reduction of stearoyl-CoA desaturase (SCD) contributes muscle atrophy through the excess endoplasmic reticulum stress in chronic kidney disease.  |  Niida, Y., et al. 2020. J Clin Biochem Nutr. 67: 179-187. PMID: 33041516
9. Stearoyl-CoA Desaturase (SCD) Induces Cardiac Dysfunction with Cardiac Lipid Overload and Angiotensin II AT1 Receptor Protein Up-Regulation.  |  Abd Alla, J., et al. 2021. Int J Mol Sci. 22: PMID: 34576047
10. Fatty acid profiles and Delta9 desaturase (stearoyl-CoA desaturase; SCD 1) expression in adipose tissue surrounding benign and malignant breast tumors.  |  Sefidabi, R., et al. 2023. Heliyon. 9: e20658. PMID: 37885725
11. The regulation of stearoyl-CoA desaturase (SCD).  |  Ntambi, JM. 1995. Prog Lipid Res. 34: 139-50. PMID: 7480063
12. Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues.  |  Li, J., et al. 1994. Int J Cancer. 57: 348-52. PMID: 7909540

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SCD Antibody (CD.E10) has 14 citations in a variety of scientific publications.

Primary antibodies like Anti-SCD Antibody (CD.E10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SCD Antibody (CD.E10) Specifications

Alternate Product Name: SCD

Product Clone Name: CD.E10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: SCD

Epitope Species: human

Product Reactivity/Detection: SCD of human origin and SCD1, SCD2, SCD3 and SCD4 of mouse and rat origin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 14 citations in various scientific publications

Available Conjugates/Forms for SCD Antibody (CD.E10): N/A

The preferred SCD antibody is SCD Antibody (A00093.01): sc-81776.