Date published: 2026-1-12

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SCD1 Inhibitors

SCD1 inhibitors belong to a class of compounds that specifically target and inhibit the activity of Stearoyl-CoA Desaturase 1 (SCD1). SCD1 is an enzyme involved in the biosynthesis of monounsaturated fatty acids (MUFAs), particularly the conversion of saturated fatty acids (SFAs) to MUFAs. By inhibiting SCD1, these compounds disrupt the normal lipid metabolism processes mediated by the enzyme. SCD1 inhibitors typically act by binding to the active site of SCD1 or interfering with its catalytic activity, thereby preventing the conversion of SFAs to MUFAs. This inhibition can lead to alterations in cellular lipid profiles and impact various physiological processes related to lipid homeostasis. SCD1 inhibitors are valuable tools for investigating the role of SCD1 in lipid metabolism and studying the implications of modulating SCD1 activity in different biological contexts. These inhibitors can provide valuable insights into the function of SCD1 and its involvement in lipid-related processes.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

CAY 10566

944808-88-2sc-205109
sc-205109A
sc-205109B
1 mg
5 mg
25 mg
$117.00
$512.00
$1527.00
4
(1)

CAY 10566 functions as a selective inhibitor of SCD1, exhibiting unique molecular interactions that target the enzyme's active site. Its structural conformation promotes specific binding, influencing lipid metabolism pathways by modulating fatty acid desaturation. The compound's kinetic profile reveals a rapid onset of action, while its solubility characteristics enable effective engagement with lipid bilayers, facilitating in-depth exploration of metabolic regulation mechanisms.

PluriSln 1

91396-88-2sc-397044
sc-397044A
10 mg
50 mg
$99.00
$415.00
(0)

PluriSln 1 acts as a selective SCD1 inhibitor, characterized by its ability to disrupt enzyme-substrate interactions through unique steric hindrance. This compound alters lipid biosynthesis pathways by stabilizing intermediate conformations, thereby affecting reaction kinetics. Its distinctive hydrophobic properties enhance membrane permeability, allowing for targeted modulation of lipid profiles. The compound's reactivity with specific functional groups further underscores its role in metabolic regulation.

5-chloro-1′-[(2-fluorophenyl)methyl]-2,2′,5′-trioxo-spiro[3H-indole-3,3′-pyrrolidine-1(2H)-acetic acid

916046-55-4sc-205132
sc-205132A
1 mg
5 mg
$70.00
$320.00
(0)

A potent SCD1 inhibitor that exhibits anti-inflammatory effects by modulating lipid metabolism.

A 922500

959122-11-3sc-203793
10 mg
$270.00
2
(1)

A potent and selective SCD1 inhibitor that has been investigated for its potential use in metabolic disorders, such as obesity and non-alcoholic fatty liver disease.

BAY 11-7085

196309-76-9sc-202490
sc-202490A
10 mg
50 mg
$124.00
$526.00
55
(2)

While primarily known as an inhibitor of NF-κB activation, BAY 11-7085 has also been reported to inhibit SCD1 activity, leading to alterations in lipid metabolism.