A 922500 (CAS 959122-11-3)
See product citations (2)
QUICK LINKS
A 922500 is frequently employed in biochemistry and molecular biology research due to its role as an inhibitor of diacylglycerol acyltransferase 1 (DGAT-1). This enzyme is integral to the synthesis of triglycerides, and by inhibiting DGAT-1, A 922500 is useful in studying lipid metabolism and energy homeostasis. Researchers utilize this compound to explore the enzyme′s function in metabolic pathways, which has implications for understanding the regulation of lipid storage in cells. Additionally, A 922500 is used in metabolic disorder studies to examine how inhibiting DGAT-1 affects lipid profiles within organisms. The compound also can provide insight into the potential mechanisms regulating appetite and energy expenditure at the molecular level.
A 922500 (CAS 959122-11-3) References
- Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor. | Zhao, G., et al. 2008. J Med Chem. 51: 380-3. PMID: 18183944
- Diacylglycerol acyltransferase 1 inhibition lowers serum triglycerides in the Zucker fatty rat and the hyperlipidemic hamster. | King, AJ., et al. 2009. J Pharmacol Exp Ther. 330: 526-31. PMID: 19478132
- In vivo efficacy of acyl CoA: diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of postprandial hyperlipidemia. | King, AJ., et al. 2010. Eur J Pharmacol. 637: 155-61. PMID: 20385122
- Intestine-targeted DGAT1 inhibition improves obesity and insulin resistance without skin aberrations in mice. | Tsuda, N., et al. 2014. PLoS One. 9: e112027. PMID: 25405858
- Profiling the role of deacylation-reacylation in the lymphatic transport of a triglyceride-mimetic prodrug. | Han, S., et al. 2015. Pharm Res. 32: 1830-44. PMID: 25446770
- Cytosolic phospholipase A2-α participates in lipid body formation and PGE2 release in human neutrophils stimulated with an L-amino acid oxidase from Calloselasma rhodostoma venom. | Paloschi, MV., et al. 2020. Sci Rep. 10: 10976. PMID: 32620771
- Inhibiting diacylglycerol acyltransferase-1 reduces lipid biosynthesis in bovine blastocysts produced in vitro. | Cañón-Beltrán, K., et al. 2020. Theriogenology. 158: 267-276. PMID: 33002770
- Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators. | Dias, SSG., et al. 2020. PLoS Pathog. 16: e1009127. PMID: 33326472
- The pro-inflammatory effect of triglyceride on human CD4+ T cells and experimental autoimmune uveitis. | Tan, S., et al. 2022. Clin Immunol. 240: 109056. PMID: 35659924
- Sulfur mustard analog 2-chloroethyl ethyl sulfide increases triglycerides by activating DGAT1-dependent biogenesis and inhibiting PGC1ɑ-dependent fat catabolism in immortalized human bronchial epithelial cells. | Ye, F., et al. 2022. Toxicol Mech Methods. 1-8. PMID: 36106344
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A 922500, 10 mg | sc-203793 | 10 mg | $265.00 |