![5-chloro-1′-[(2-fluorophenyl)methyl]-2,2′,5′-trioxo-spiro[3H-indole-3,3′-pyrrolidine-1(2H)-acetic acid (CAS 916046-55-4) - ch](https://media.scbt.com/product/5-chloro-1prime-2-fluorophenylmethyl-2-2prime-5prime-trioxo-spiro3h-indole-3-3prime-pyrrolidine-12h-acetic-acid-916046-55-4-structure_07_36_b_73694.jpg)
![5-chloro-1′-[(2-fluorophenyl)methyl]-2,2′,5′-trioxo-spiro[3H-indole-3,3′-pyrrolidine-1(2H)-acetic acid (CAS 916046-55-4) - ch](https://media.scbt.com/product/5-chloro-1prime-2-fluorophenylmethyl-2-2prime-5prime-trioxo-spiro3h-indole-3-3prime-pyrrolidine-12h-acetic-acid-916046-55-4-structure_07_36_t_73694.jpg "Molecular structure of 5-chloro-1′-[(2-fluorophenyl)methyl]-2,2′,5′-trioxo-spiro[3H-indole-3,3′-pyrrolidine-1(2H)-acetic acid, CAS Number: 916046-55-4")
Molecular structure of 5-chloro-1′-[(2-fluorophenyl)methyl]-2,2′,5′-trioxo-spiro[3H-indole-3,3′-pyrrolidine-1(2H)-acetic acid, CAS Number: 916046-55-4
5-chloro-1′-[(2-fluorophenyl)methyl]-2,2′,5′-trioxo-spiro[3H-indole-3,3′-pyrrolidine-1(2H)-acetic acid (CAS 916046-55-4)
Alternate Names:
5-chloro-1'-[(2-fluorophenyl)methyl]-2,2',5'-trioxo-spiro[3H-indole-3,3'-pyrrolidine-1(2H)-acetic acid
Application:
5-chloro-1′-[(2-fluorophenyl)methyl]-2,2′,5′-trioxo-spiro[3H-indole-3,3′-pyrrolidine-1(2H)-acetic acid is a DP2/CRTH2 receptor antagonist
CAS Number:
916046-55-4
Molecular Weight:
416.8
Molecular Formula:
C20H14ClFN2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
A potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 37 nM.2 The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on eosinophils, basophils and Th2 cells where it mediates the chemotactic activity of PGD2.1 The R enantiomer is slightly more potent exhibiting Ki values of 23 and 22 nM at the human and murine CRTH2/DP2 receptor, respectively. The R enantiomer inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-PGD2 with an IC50 value of 40 nM.2
5-chloro-1′-[(2-fluorophenyl)methyl]-2,2′,5′-trioxo-spiro[3H-indole-3,3′-pyrrolidine-1(2H)-acetic acid (CAS 916046-55-4) References
- Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. | Hirai, H., et al. 2001. J Exp Med. 193: 255-61. PMID: 11208866
- Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases. | Crosignani, S., et al. 2008. J Med Chem. 51: 2227-43. PMID: 18318469
Inhibitor of:
DP2, and SCD1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-chloro-1'-[(2-fluorophenyl)methyl]-2,2',5'-trioxo-spiro[3H-indole-3,3'-pyrrolidine-1(2H)-acetic acid, 1 mg | sc-205132 | 1 mg | $70.00 | |||
5-chloro-1'-[(2-fluorophenyl)methyl]-2,2',5'-trioxo-spiro[3H-indole-3,3'-pyrrolidine-1(2H)-acetic acid, 5 mg | sc-205132A | 5 mg | $320.00 |