SCD1 Activators
Stearoyl-CoA desaturase 1 (SCD1) is a key enzyme in lipid metabolism, playing a pivotal role in the conversion of saturated fatty acids (SFAs) to monounsaturated fatty acids (MUFAs). This enzymatic process is critical for maintaining cellular lipid homeostasis, influencing membrane fluidity, and participating in various signaling pathways. SCD1's activity is essential for the biosynthesis of oleic acid and palmitoleic acid, which are fundamental components of cellular membranes and are involved in numerous biological processes, including the regulation of energy metabolism, inflammation, and cell proliferation. The regulation of SCD1 is complex, influenced by nutritional status, hormonal signals, and intracellular lipid levels, highlighting its central role in integrating metabolic signals and modifying cellular lipid composition in response to changing physiological conditions.
Activation of SCD1 involves the catalytic conversion of specific SFAs to MUFAs. This activity not only impacts the structural components of cell membranes but also affects the cellular signaling pathways, including those related to insulin sensitivity, inflammation, and energy homeostasis. The presence and availability of substrates such as palmitic acid and stearic acid are crucial for SCD1's enzymatic function. Moreover, the enzyme's activity can be influenced indirectly by alterations in the cellular environment, such as changes in the levels of polyunsaturated fatty acids, which can modulate the demand for SCD1's desaturation process. Understanding the biochemical and cellular pathways that regulate SCD1 activity is fundamental to elucidating its role in health and disease. Despite the lack of direct chemical activators, the modulation of SCD1 through indirect pathways offers insights into the enzyme's adaptive responses to cellular metabolic states, highlighting its importance in maintaining lipid homeostasis and cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic acid, a monounsaturated fatty acid, can enhance SCD1 activity by serving as a substrate. SCD1 catalyzes the conversion of saturated fatty acids to monounsaturated fatty acids, thus oleic acid's presence increases the substrate availability, leading to increased enzyme activity. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $34.00 $64.00 $166.00 $281.00 | 4 | |
Linoleic acid, a polyunsaturated fatty acid, indirectly activates SCD1 by increasing the demand for its enzymatic activity. SCD1 converts saturated fatty acids to monounsaturated forms, and the presence of linoleic acid shifts cellular lipid profiles, enhancing SCD1's functional role in maintaining membrane fluidity. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic acid promotes SCD1 activity by altering the lipid composition of membranes. This change in lipid composition requires SCD1 to convert more saturated fatty acids into monounsaturated fatty acids, thus indirectly enhancing the enzyme's activity to adjust membrane fluidity and function. | ||||||
Palmitoleic acid | 373-49-9 | sc-205424 sc-205424A sc-205424B sc-205424C sc-205424D | 100 mg 500 mg 1 g 5 g 10 g | $33.00 $135.00 $238.00 $1039.00 $1907.00 | 4 | |
Palmitoleic acid serves as a direct substrate for SCD1, facilitating its enzymatic function of desaturating saturated fatty acids. The presence of palmitoleic acid underscores the enzyme's role in lipid metabolism, leading to an increase in SCD1 activity to produce monounsaturated fatty acids. | ||||||
Conjugated Linoleic Acid (10E,12Z) | 2420-56-6 | sc-223898 sc-223898A sc-223898B | 10 mg 25 mg 50 mg | $243.00 $386.00 $685.00 | ||
Conjugated Linoleic Acid impacts SCD1 activity by interacting with lipid metabolism pathways. This interaction can lead to an upregulated activity of SCD1 as the enzyme adjusts to changes in the cellular demand for monounsaturated fatty acids, indicating an indirect mode of activation. | ||||||
α-Linolenic Acid | 463-40-1 | sc-205545 sc-205545A | 50 mg 250 mg | $38.00 $115.00 | 2 | |
Alpha-Linolenic Acid impacts SCD1 by contributing to the pool of polyunsaturated fatty acids, which necessitates increased activity of SCD1 to maintain cellular lipid homeostasis, thus indirectly activating SCD1 to enhance the synthesis of monounsaturated fatty acids. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $94.00 $210.00 $1779.00 $8021.00 $16657.00 | 11 | |
DHA indirectly activates SCD1 by altering cellular lipid composition, which could increase the need for SCD1’s activity in producing monounsaturated fatty acids for maintaining membrane fluidity and signaling functions, showcasing an indirect pathway of activation. | ||||||
Myristic Acid | 544-63-8 | sc-205393 sc-205393A sc-205393B | 1 g 5 g 50 g | $31.00 $77.00 $306.00 | 1 | |
Myristoleic acid directly serves as a substrate for SCD1, necessitating its enzymatic action for the conversion of saturated to monounsaturated fatty acids. This direct interaction with the enzyme underscores its role in lipid metabolism and cellular energy homeostasis. | ||||||
Lauric Acid | 143-07-7 | sc-205367 sc-205367A sc-205367B | 25 g 100 g 250 g | $31.00 $36.00 $79.00 | 1 | |
While not a direct activator, lauric acid can increase the demand for SCD1 activity by contributing to the saturated fatty acid pool, necessitating SCD1's function in converting these to monounsaturated fatty acids for proper cell function and signaling. | ||||||
Stearic Acid | 57-11-4 | sc-203408 sc-203408A sc-203408B | 100 g 1 kg 5 kg | $26.00 $32.00 $117.00 | 1 | |
Stearic acid can enhance SCD1 activity by serving as a direct substrate, where SCD1 catalyzes its conversion to oleic acid. This substrate-specific interaction underscores SCD1's critical role in the biosynthesis of monounsaturated fatty acids. | ||||||