SATB2 Antibody (G-11): sc-518006
- SATB2 Antibody (G-11) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 225-342 mapping within an internal region of SATB2 of human origin
- Anti-SATB2 Antibody (G-11) is recommended for detection of SATB2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-SATB2 Antibody (G-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SATB2 Antibody (G-11) for WB applications. These reagents are now offered in bundles with SATB2 Antibody (G-11) (see ordering information below).
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SATB2 Antibody (G-11) is a mouse monoclonal IgG2a kappa light chain antibody that detects SATB2 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SATB2 (G-11) antibody is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SATB2, or Special AT-rich sequence-binding protein 2, is a crucial nuclear matrix protein that plays a significant role in craniofacial development, particularly in jaw and palate formation, and regulates skeletal development and osteoblast differentiation. SATB2 is predominantly expressed in adult and fetal brain and features two CUT DNA-binding domains along with a homeobox domain, essential for function. SATB2 is closely related to SATB1, a known transcriptional repressor, and interacts with matrix-attachment regions (MARs) to modulate transcription of various genes, including HoxA2 and ATF4 (CREB-2), both vital for skeletal development. As both a transcriptional activator and repressor, SATB2 can serve as a protein scaffold, enhancing DNA-binding protein activity. Mutations in SATB2 are linked to cleft palate and severe cognitive impairments, underscoring SATB2′s critical role in developmental biology and potential clinical implications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SATB2 Antibody (G-11) References:
- The role of SATB2 in skeletogenesis and human disease. | Zhao, X., et al. 2014. Cytokine Growth Factor Rev. 25: 35-44. PMID: 24411565
- Prognostic value of SATB2 expression in patients with esophageal squamous cell carcinoma. | Geng, GJ., et al. 2015. Int J Clin Exp Pathol. 8: 423-31. PMID: 25755730
- Satb2 regulates proliferation and nuclear integrity of pre-osteoblasts. | Dowrey, T., et al. 2019. Bone. 127: 488-498. PMID: 31325654
- SATB2 is a novel biomarker and therapeutic target for cancer. | Roy, SK., et al. 2020. J Cell Mol Med. 24: 11064-11069. PMID: 32885593
- SATB2-associated syndrome in adolescents and adults. | Zarate, YA., et al. 2021. Am J Med Genet A. 185: 2391-2398. PMID: 33969926
- SATB2: A versatile transcriptional regulator of craniofacial and skeleton development, neurogenesis and tumorigenesis, and its applications in regenerative medicine. | Huang, X., et al. 2022. Genes Dis. 9: 95-107. PMID: 35005110
- SATB2 is expressed in neuroendocrine carcinoma of the uterine cervix. | Inzani, F., et al. 2022. Virchows Arch. 480: 873-877. PMID: 35091815
- SATB2 Expression in Undifferentiated Pleomorphic Sarcomas of Bone. | Warmke, LM., et al. 2022. Am J Clin Pathol. 158: 235-241. PMID: 35311957
- Growth in individuals with SATB2-associated syndrome. | Zarate, YA., et al. 2022. Am J Med Genet A. 188: 2952-2957. PMID: 35838081
- Psammomatoid Ossifying Fibroma Is Defined by SATB2 Rearrangement. | Cleven, AHG., et al. 2023. Mod Pathol. 36: 100013. PMID: 36788065
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SATB2 Antibody (G-11) | sc-518006 | 200 µg/ml | $322.00 | |||
SATB2 Antibody (G-11): m-IgG Fc BP-HRP Bundle | sc-531589 | 200 µg Ab; 10 µg BP | $361.00 | |||
SATB2 Antibody (G-11): m-IgGκ BP-HRP Bundle | sc-525320 | 200 µg Ab, 40 µg BP | $361.00 | |||
SATB2 Antibody (G-11): m-IgG2a BP-HRP Bundle | sc-547822 | 200 µg Ab; 10 µg BP | $361.00 | |||
SATB2 Antibody (G-11) AC | sc-518006 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SATB2 Antibody (G-11) HRP | sc-518006 HRP | 200 µg/ml | $322.00 | |||
SATB2 Antibody (G-11) FITC | sc-518006 FITC | 200 µg/ml | $336.00 | |||
SATB2 Antibody (G-11) PE | sc-518006 PE | 200 µg/ml | $349.00 | |||
SATB2 Antibody (G-11) Alexa Fluor® 488 | sc-518006 AF488 | 200 µg/ml | $364.00 | |||
SATB2 Antibody (G-11) Alexa Fluor® 546 | sc-518006 AF546 | 200 µg/ml | $364.00 | |||
SATB2 Antibody (G-11) Alexa Fluor® 594 | sc-518006 AF594 | 200 µg/ml | $364.00 | |||
SATB2 Antibody (G-11) Alexa Fluor® 647 | sc-518006 AF647 | 200 µg/ml | $364.00 | |||
SATB2 Antibody (G-11) Alexa Fluor® 680 | sc-518006 AF680 | 200 µg/ml | $364.00 | |||
SATB2 Antibody (G-11) Alexa Fluor® 790 | sc-518006 AF790 | 200 µg/ml | $364.00 |