Rsk-1 Antibody (10B1D7): sc-81162
- Rsk-1 Antibody (10B1D7) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against a recombinant protein corresponding to amino acids 581-735 of Rsk-1 of human origin
- recommended for detection of Rsk-1 of human origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Rsk-1 Antibody (10B1D7). This work is in progress.
Rsk-1 Antibody (10B1D7) is a mouse monoclonal IgG2a antibody that detects Rsk-1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Rsk-1, also known as MAPKAP kinase-1, is a crucial serine/threonine kinase that serves as a key signaling intermediate in various cellular responses to ligand-activated receptor tyrosine kinases. One of the notable aspects of Rsk-1 is its unique structure, which features two non-identical complete kinase catalytic domains, allowing Rsk-1 to integrate multiple signaling pathways effectively. This structural complexity is essential for Rsk-1′s role in mediating cellular processes such as growth, differentiation, and survival, particularly in response to stress signals. Rsk-1 is predominantly expressed in tissues such as the brain and kidney, where Rsk-1 contributes to normal neuronal development and function. The ability of anti-Rsk-1 antibody (10B1D7) to interact with other proteins, including members of the Rsk family and various signaling molecules, further underscores Rsk-1′s importance in cellular signaling networks. Rsk-1 (10B1D7) monoclonal antibody is an invaluable tool for researchers studying the intricate roles of this protein in health and disease.
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Rsk-1 Antibody (10B1D7) References:
- Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK. | Richards, SA., et al. Curr Biol. 9: 810-20. PMID: 10469565
- p90 RSK-1 associates with and inhibits neuronal nitric oxide synthase. | Song, T., et al. 2007. Biochem J. 401: 391-8. PMID: 16984226
- Involvement of polo-like kinase 1 (Plk1) in mitotic arrest by inhibition of mitogen-activated protein kinase-extracellular signal-regulated kinase-ribosomal S6 kinase 1 (MEK-ERK-RSK1) cascade. | Li, R., et al. 2012. J Biol Chem. 287: 15923-34. PMID: 22427657
- Involvement of RSK1 activation in malformin-enhanced cellular fibrinolytic activity. | Koizumi, Y., et al. 2018. Sci Rep. 8: 5472. PMID: 29615689
- Aberrant expression of RSK1 characterizes high-grade gliomas with immune infiltration. | M Hajj, GN., et al. 2020. Mol Oncol. 14: 159-179. PMID: 31701625
- RSK1 SUMOylation is required for KSHV lytic replication. | Liu, Z., et al. 2021. PLoS Pathog. 17: e1010123. PMID: 34871326
- RSK1 promotes mammalian axon regeneration by inducing the synthesis of regeneration-related proteins. | Mao, S., et al. 2022. PLoS Biol. 20: e3001653. PMID: 35648763
- RSK1 dependency in FLT3-ITD acute myeloid leukemia. | Kong, T., et al. 2024. Blood Cancer J. 14: 207. PMID: 39592591
- RSK1 and RSK2 as therapeutic targets: an up-to-date snapshot of emerging data. | Spirrison, AN. and Lannigan, DA. 2024. Expert Opin Ther Targets. 28: 1047-1059. PMID: 39632509
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rsk-1 Antibody (10B1D7) | sc-81162 | 200 µg/ml | $322.00 |