Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
RORβ Antibody (4B4) is a high quality monoclonal ROR beta antibody (also designated RORβ antibody) suitable for the detection of the ROR beta protein of mouse, rat and human origin. RORβ Antibody (4B4) is available as the non-conjugated anti-ROR beta antibody. Nuclear receptors that lack a defined ligand are classified as orphan nuclear receptors. Retinoic acid receptor-related orphan nuclear receptor (ROR) proteins RORα, RORβ and RORγ are members of the nuclear hormone receptor superfamily. Unlike other members of the nuclear hormone receptor superfamily that bind DNA as homo- or heterodimers, ROR proteins directly bind the hormone response element (HRE) DNA sequence as monomers. RORα has multiple isoforms that share common DNA- and putative ligand-binding domains, but differ in their amino-terminal domains, which are generated by alternative RNA processing. RORβ is primarily expressed in brain and other areas of the central nervous system that process sensory information. The expression levels of RORβ oscillate in the retina and pineal gland with a circadian rhythm. In Neuro2A cells, RORβ binds DNA and efficiently directs transcription. The gene encoding human RORβ maps to chromosome 9q22. RORγ comprises a 560 amino acid protein that shares 50% amino acid identity with RORα and is most highly expressed in skeletal muscle.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
For Western Blot, is it recommended to use denatured or non-denatured conditions with RORβ (4B4): sc-293471 antibody?
Asked by: Randy McDonald
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
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