RORβ Antibody (4B4): sc-293471

RORβ Antibody (4B4) is a mouse monoclonal IgG1 kappa light chain antibody that detects RORβ protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-RORβ antibody (4B4) is available as the non-conjugated format. RORβ protein plays a crucial role in the regulation of circadian rhythms and is primarily expressed in the brain and central nervous system, particularly in regions that process sensory information. RORβ expression levels exhibit oscillation in the retina and pineal gland, aligning with the body′s circadian clock, which is vital for maintaining physiological homeostasis and influencing sleep-wake cycles. RORβ is involved in the transcriptional regulation of genes that are essential for neuronal development and function, making RORβ a significant target for research in neurobiology and circadian biology. The gene encoding human RORβ is located on chromosome 9q22, and RORβ′s unique ability to bind DNA as a monomer distinguishes RORβ from other members of the nuclear hormone receptor superfamily, which typically function as dimers. This characteristic underlines RORβ′s importance in mediating specific gene expression patterns that are critical for various biological processes.

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RORβ Antibody (4B4) References:

1. Differential binding and transcriptional behaviour of two highly related orphan receptors, ROR alpha(4) and ROR beta(1).  |  Gawlas, K. and Stunnenberg, HG. 2000. Biochim Biophys Acta. 1494: 236-41. PMID: 11121580
2. Differential transcription of the orphan receptor RORbeta in nuclear extracts derived from Neuro2A and HeLa cells.  |  Gawlas, K. and Stunnenberg, HG. 2001. Nucleic Acids Res. 29: 3424-32. PMID: 11504880
3. Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development.  |  Jia, L., et al. 2009. Proc Natl Acad Sci U S A. 106: 17534-9. PMID: 19805139
4. Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORβ and RORγt.  |  Gege, C., et al. 2014. Bioorg Med Chem Lett. 24: 5265-7. PMID: 25305688
5. Retinoic acid-related orphan receptor RORβ, circadian rhythm abnormalities and tumorigenesis (Review).  |  Feng, S., et al. 2015. Int J Mol Med. 35: 1493-500. PMID: 25816151
6. Osteoprotection Through the Deletion of the Transcription Factor Rorβ in Mice.  |  Farr, JN., et al. 2018. J Bone Miner Res. 33: 720-731. PMID: 29206307
7. Arsenic Trioxide Induces Retinoic Acid-Related Orphan Receptor Beta and Blocks the WNT Pathway to Inhibit Stemness in Glioblastoma.  |  Ding, D., et al. 2024. Tohoku J Exp Med. 263: 199-210. PMID: 38797699
8. ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle.  |  Hirose, T., et al. 1994. Biochem Biophys Res Commun. 205: 1976-83. PMID: 7811290
9. Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors.  |  Giguère, V., et al. 1994. Genes Dev. 8: 538-53. PMID: 7926749
10. RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers.  |  Carlberg, C., et al. 1994. Mol Endocrinol. 8: 757-70. PMID: 7935491
11. The nuclear receptor superfamily: the second decade.  |  Mangelsdorf, DJ., et al. 1995. Cell. 83: 835-9. PMID: 8521507
12. Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice.  |  André, E., et al. 1998. EMBO J. 17: 3867-77. PMID: 9670004

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RORβ Antibody (4B4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-RORβ Antibody (4B4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RORβ Antibody (4B4) Specifications

Alternate Product Name: RORB

Product Clone Name: 4B4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 136-224

Epitope Target: RORβ

Epitope Species: human

Product Reactivity/Detection: RORβ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for RORβ Antibody (4B4): N/A