RORβ Activators
RORβ Activators are a group of chemicals that enhance the functional activity of RORβ primarily through influencing the retinoid X receptor (RXR), peroxisome proliferator-activated receptors (PPARs), and other ROR subtypes. These activators, which include RXR agonists such as bexarotene, fenretinide, LG100268, SR11237, and SR11253, bind to and activate RXR. RORβ can form heterodimers with RXR, and the activation of RXR can enhance the transcriptional activity of RORβ. Thus, by stimulating RXR, these compounds directly enhance the transcriptional activity of RORβ.
Moreover, RORβ Activators include PPARγ agonists like rosiglitazone, pioglitazone, and troglitazone. PPARγ can form heterodimers with RXR, which can then interact with RORβ. Activation of PPARγ can indirectly enhance RORβ activity through these interactions. RORβ Activators also include chemicals that act on RORα and RORγ, such as SR1001 and ursolic acid. The action on these receptors can shift the balance of ROR activity within the cell and indirectly enhance the activity of RORβ. Similarly, T0901317, an agonist of liver X receptors (LXRs) that also has off-target effects on RORs, can enhance RORβ activity indirectly through its action on these related receptors. Through these specific mechanisms, the compounds listed above can enhancethe functional activity of RORβ. Melatonin, a hormone known to regulate circadian rhythms, also falls under the category of RORβ Activators due to its regulatory effects on RORα and RORβ expression and activity in certain tissues. In this manner, melatonin can potentially lead to enhanced RORβ activity. This diverse group of RORβ Activators, therefore, influences a range of pathways and receptors that can directly or indirectly enhance RORβ activity. By targeting related receptors or shifting the balance of activity among ROR subtypes, these activators can have a substantial effect on RORβ activity. Through these varied mechanisms, the RORβ Activators serve as a significant tool in the study of RORβ and its associated pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bexarotene | 153559-49-0 | sc-217753 sc-217753A | 10 mg 100 mg | $55.00 $250.00 | 6 | |
Bexarotene is a retinoid X receptor (RXR) agonist. RXR can form heterodimers with RORβ, and activation of RXR can enhance the transcriptional activity of RORβ. | ||||||
SR 1001 | 1335106-03-0 | sc-507320 | 5 mg | $150.00 | ||
SR1001 is an agonist for RORα and RORγ. The action on these receptors can shift the balance of ROR activity within the cell and indirectly enhance the activity of RORβ. | ||||||
Melatonin | 73-31-4 | sc-207848 sc-207848A sc-207848B sc-207848C sc-207848D sc-207848E | 1 g 5 g 25 g 100 g 250 g 1 kg | $65.00 $73.00 $218.00 $697.00 $1196.00 $3574.00 | 16 | |
Melatonin is known to regulate RORα and RORβ expression and activity in certain tissues, potentially leading to enhanced RORβ activity. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $56.00 $180.00 | 8 | |
Ursolic acid has been reported to bind and activate RORα and RORγ, which could indirectly stimulate RORβ activity by shifting the balance of ROR activity within the cell. | ||||||
T 0901317 | 293754-55-9 | sc-202824 sc-202824A | 10 mg 50 mg | $89.00 $224.00 | 5 | |
T0901317 is an agonist of liver X receptors (LXRs) that also has off-target effects on RORs. It can enhance RORβ activity indirectly through its action on these related receptors. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone is a PPARγ agonist. PPARγ can form heterodimers with RXR, which in turn can interact with RORβ. Activation of PPARγ can thus indirectly enhance RORβ activity. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Similar to rosiglitazone, pioglitazone is a PPARγ agonist. Its activation of PPARγ can indirectly enhance RORβ activity through interactions with RXR. | ||||||
4-Hydroxyphenylretinamide | 65646-68-6 | sc-200900 sc-200900A | 5 mg 25 mg | $104.00 $315.00 | ||
Fenretinide is a synthetic retinoid that can bind and activate RXR. Activation of RXR can lead to enhanced RORβ activity, as RXR can form heterodimers with RORβ. | ||||||
CD 437 | 125316-60-1 | sc-202527 | 5 mg | $121.00 | ||
LG100268 is a selective RXR agonist. Activation of RXR by LG100268 can enhance RORβ activity, given the ability of RXR to heterodimerize with RORβ. | ||||||
SR 11237 | 146670-40-8 | sc-296418 sc-296418A | 5 mg 50 mg | $211.00 $877.00 | ||
SR11237 is an agonist of RXR. Its activation of RXR can lead to enhanced RORβ activity, as RXR can form heterodimers with RORβ. | ||||||