RhoC Antibody (37): sc-130339

Rho C Antibody (37) is a mouse monoclonal IgG1 antibody raised against recombinant human Rho C, suitable for applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA), and shows species reactivity with human proteins. Rho C is a small GTPase belonging to the Rho family within the Ras superfamily, playing a pivotal role in regulating the actin cytoskeleton, cell shape, motility, and adhesion. RhoC (37) monoclonal antibody functions as a molecular switch by cycling between an active GTP-bound state and an inactive GDP-bound state, thus influencing signal transduction pathways that control various cellular processes. RhoC (37) antibody′s target is critically important because overexpression or hyperactivation is associated with increased invasiveness and metastatic potential in several human cancers, including breast cancer, pancreatic cancer, and melanoma. Understanding Rho C′s role in cancer progression and metastasis is essential for developing targeted therapeutic strategies, making anti-RhoC antibody (37) a valuable tool for researchers investigating cell migration, cytoskeletal dynamics, and oncogenic signaling pathways.

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RhoC Antibody (37) References:

1. Phenotypic profiling of engineered mouse melanomas with manipulated histamine production identifies histamine H2 receptor and rho-C as histamine-regulated melanoma progression markers.  |  Pós, Z., et al. 2005. Cancer Res. 65: 4458-66. PMID: 15899839
2. Epidermal growth factor stimulates human trophoblast cell migration through Rho A and Rho C activation.  |  Han, J., et al. 2010. Endocrinology. 151: 1732-42. PMID: 20150581
3. Marsdenia tenacissima extract suppresses A549 cell migration through regulation of CCR5-CCL5 axis, Rho C, and phosphorylated FAK.  |  Lin, SS., et al. 2016. Chin J Nat Med. 14: 203-9. PMID: 27025367
4. Magnetic behavior of a ferroferrimagnetic ternary alloy AB_{ρ}C_{1-ρ} with a selective site disorder: Case study of a mixed-spin Ising model on a honeycomb lattice.  |  Torrico, J., et al. 2020. Phys Rev E. 101: 032104. PMID: 32289902
5. Estimation of Critical Constants Tc, ρ c from the ρ(T) and T(ρ) Relations at Coexistence.  |  Goodwin, RD. 1970. J Res Natl Bur Stand A Phys Chem. 74A: 221-227. PMID: 32523180
6. Leukemia-Associated Rho Guanine Nucleotide Exchange Factor and Ras Homolog Family Member C Play a Role in Glioblastoma Cell Invasion and Resistance.  |  Ding, Z., et al. 2020. Am J Pathol. 190: 2165-2176. PMID: 32693062
7. MicroRNA-20b-5p aggravates neuronal apoptosis induced by β-Amyloid via down-regulation of Ras homolog family member C in Alzheimer's disease.  |  Tian, Z., et al. 2021. Neurosci Lett. 742: 135542. PMID: 33278507
8. Prevalence Estimates and Genetic Diversity for Autosomal Dominant Retinitis Pigmentosa Due to RHO, c.68C>A (p.P23H) Variant.  |  Leenders, M., et al. 2024. Am J Ophthalmol. 268: 340-347. PMID: 39278389
9. Effect of silencing Ras homolog family member C on proliferation, invasion, and migration of salivary adenoid cystic carcinoma.  |  Yu, W., et al. 2024. Hua Xi Kou Qiang Yi Xue Za Zhi. 42: 723-734. PMID: 39610069
10. Reassignment of the human ARH9 RAS-related gene to chromosome 1p13-p21.  |  Morris, SW., et al. 1993. Genomics. 15: 677-9. PMID: 8468062

The preferred RhoC antibody is RhoC Antibody (C-10): sc-393090.