RhD Antibody (55/2): sc-52432
- RhD Antibody (55/2) is a mouse monoclonal IgM RhD antibody provided at 100 µg/ml
- raised against Rhesus blood group antigen D of human origin
- recommended for detection of Rhesus blood group antigen D of human origin by WB, IP, IF and FCM
- available conjugated to FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for RhD Antibody (55/2). This work is in progress.
RhD Antibody (55/2) is a mouse monoclonal IgM antibody that detects the RhD protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-RhD antibody (55/2) is available in both non-conjugated and various conjugated forms, including fluorescein isothiocyanate (FITC), providing versatility for different experimental needs. RhD protein plays a critical role in the Rhesus blood group system, which is one of the most complex and significant blood group systems in humans. The RHD gene, which encodes the D antigen, is essential for determining RhD blood type and is often deleted in a significant portion of the population. This deletion can lead to Rh incompatibility during pregnancy, resulting in hemolytic disease of the newborn (HDN), a serious condition that can lead to fetal death. RhD protein is an integral membrane protein characterized by its 12-transmembrane helices, which are crucial for maintaining erythrocyte membrane integrity. Additionally, the proper presentation of Rh antigenic activity necessitates the formation of a complex between the RHCED antigens and RHAG (RH50), highlighting the importance of these interactions in blood group immunology. RhD monoclonal antibody (55/2) is an invaluable tool for researchers studying blood group antigens and their implications in transfusion medicine and prenatal care.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RhD Antibody (55/2) References:
- RHD gene deletion occurred in the Rhesus box. | Wagner, FF. and Flegel, WA. 2000. Blood. 95: 3662-8. PMID: 10845894
- Haemolytic disease of newborn. | Narang, A. and Jain, N. 2001. Indian J Pediatr. 68: 167-72. PMID: 11284186
- [Molecular genetics and clinical application of Rh blood group system]. | Zhang, J., et al. 2002. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 19: 246-9. PMID: 12048689
- Organization of the gene (RHCE) encoding the human blood group RhCcEe antigens and characterization of the promoter region. | Chérif-Zahar, B., et al. 1994. Genomics. 19: 68-74. PMID: 8188244
- Molecular genetic basis of the human Rhesus blood group system. | Mouro, I., et al. 1993. Nat Genet. 5: 62-5. PMID: 8220426
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RhD Antibody (55/2) | sc-52432 | 100 µg/ml | $316.00 | |||
RhD Antibody (55/2) FITC | sc-52432 FITC | 100 tests in 2 ml | $330.00 |