RhD Activators
RhD activators belong to a distinctive chemical class that plays a pivotal role in the regulation of the RhD antigen, a critical component of the Rh blood group system. The RhD antigen, also known as the Rhesus factor, is a protein expressed on the surface of red blood cells. It holds significant importance in blood transfusion and pregnancy scenarios, as the presence or absence of the RhD antigen determines an individual's Rh status. RhD activators, through their unique molecular properties, influence the expression and activity of the RhD antigen.
The molecular mechanisms underlying RhD activation involve intricate interactions with the cellular machinery responsible for the synthesis and presentation of the RhD antigen. These activators can modulate the expression levels of the RhD protein on the red blood cell membrane, influencing the overall Rh phenotype of an individual. Understanding the precise biochemical pathways through which RhD activators operate is crucial for deciphering the complexities of blood compatibility and transfusion medicine. Ongoing research in this field aims to elucidate the structural aspects of RhD activators and their interactions with the RhD antigen, shedding light on the finer details of blood group determination and potentially offering insights into novel approaches for managing blood-related complications.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diester of phorbol and acts as a potent tumor promoter. It targets protein kinase C (PKC), leading to its activation. As RhD is a Rhesus protein found on red blood cells, and PKC is known to be involved in regulating cell adhesion, the activation of PKC by PMA could enhance the functional activity of RhD by promoting interaction with other membrane proteins. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a mobile ion-carrier that forms a stable complex with divalent cations (mainly Ca2+). It induces influx of extracellular Ca2+ into the cell. RhD, being a membrane protein, could be activated by Ca2+-mediated signaling events, especially those related to cell adhesion and membrane integrity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a labdane diterpene that is known to activate adenylyl cyclase, leading to an increase in cAMP levels. Increased cAMP can activate PKA (protein kinase A), which could, in turn, influence RhD function through downstream signaling mechanisms. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, it could enhance phosphorylation events in the cell, potentially influencing the functional activity of RhD. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent PKC inhibitor. It can affect membrane protein activity through changes in PKC activity, potentially leading to changes in RhD activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, it could indirectly enhance phosphorylation events in the cell, possibly influencing the functional activity of RhD. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is a calcium channel blocker that can influence the calcium ion concentration in cells. Changes in intracellular calcium can trigger several signaling pathways, potentially influencing RhD function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is a specific inhibitor of mTOR (mammalian target of rapamycin), which plays a key role in protein synthesis and cell growth. While it does not directly enhance RhD, the inhibition of mTOR could lead to changes in cell growth and membrane protein functions, indirectly affecting RhD activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in intracellular calcium levels. This could affect RhD function, given the role of calcium in cell adhesion and membrane integrity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P is a bioactive lipid that acts as a potent activator of several signaling pathways, including those related to cell growth and survival. Its influence on these pathways could indirectly impact RhD function. | ||||||