RGS4 Antibody (D-8): sc-398658
- RGS4 Antibody (D-8) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 41-80 mapping near the N-terminus of RGS4 of human origin
- recommended for detection of RGS4 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including porcine
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RGS4 Antibody (D-8) for WB applications. These reagents are now offered in bundles with RGS4 Antibody (D-8) (see ordering information below).
RGS4 Antibody (D-8) is a mouse monoclonal IgG1 antibody that detects RGS4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RGS4 plays a crucial role in the regulation of G protein signaling pathways, acting as a GTPase-activating protein that enhances the hydrolysis of GTP to GDP on specific Gα subunits, thereby modulating their activity and influencing various physiological processes. This regulation is vital for maintaining cellular homeostasis and ensuring proper signal transduction, as dysregulation of G protein signaling can lead to a range of diseases, including cancer and cardiovascular disorders. RGS4 is predominantly localized in the cytoplasm and can translocate to the plasma membrane, where RGS4 interacts with G protein-coupled receptors, further emphasizing RGS4′s importance in cellular signaling dynamics. Anti-RGS4 antibody (D-8) is an essential tool for researchers investigating the intricate mechanisms of G protein signaling and its implications in health and disease.
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RGS4 Antibody (D-8) References:
- Correlation of RGS4 and P16 expressions with pediatric nephroblastoma and its significance on prognosis. | Liu, XX., et al. 2017. Eur Rev Med Pharmacol Sci. 21: 4577-4583. PMID: 29131258
- Striatal Rgs4 regulates feeding and susceptibility to diet-induced obesity. | Michaelides, M., et al. 2020. Mol Psychiatry. 25: 2058-2069. PMID: 29955167
- RGS4 Maintains Chronic Pain Symptoms in Rodent Models. | Avrampou, K., et al. 2019. J Neurosci. 39: 8291-8304. PMID: 31308097
- RGS4 Regulates Proliferation And Apoptosis Of NSCLC Cells Via microRNA-16 And Brain-Derived Neurotrophic Factor. | He, Z., et al. 2019. Onco Targets Ther. 12: 8701-8714. PMID: 31695428
- RGS4 promotes allergen- and aspirin-associated airway hyperresponsiveness by inhibiting PGE2 biosynthesis. | Wong, GS., et al. 2020. J Allergy Clin Immunol. 146: 1152-1164.e13. PMID: 32199913
- Synergistic regulation of Rgs4 mRNA by HuR and miR-26/RISC in neurons. | Ehses, J., et al. 2021. RNA Biol. 18: 988-998. PMID: 32779957
- RGS4-Deficiency Alters Intracellular Calcium and PKA-Mediated Control of Insulin Secretion in Glucose-Stimulated Beta Islets. | Bastin, G., et al. 2021. Biomedicines. 9: PMID: 34440212
- Regulator of G-Protein Signalling 4 (RGS4) negatively modulates nociceptin/orphanin FQ opioid receptor signalling: Implication for l-Dopa-induced dyskinesia. | Pisanò, CA., et al. 2023. Br J Pharmacol. 180: 927-942. PMID: 34767639
- Cardiac RGS Proteins in Human Heart Failure and Atrial Fibrillation: Focus on RGS4. | Borges, JI., et al. 2023. Int J Mol Sci. 24: PMID: 37047106
- MGST3 regulates BACE1 protein translation and amyloidogenesis by controlling the RGS4-mediated AKT signaling pathway. | Pu, Y., et al. 2024. J Biol Chem. 300: 107530. PMID: 38971310
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RGS4 Antibody (D-8) | sc-398658 | 200 µg/ml | $322.00 | |||
RGS4 Antibody (D-8): m-IgG Fc BP-HRP Bundle | sc-538490 | 200 µg Ab; 10 µg BP | $361.00 | |||
RGS4 Antibody (D-8): m-IgGκ BP-HRP Bundle | sc-536114 | 200 µg Ab; 40 µg BP | $361.00 | |||
RGS4 Antibody (D-8): m-IgG1 BP-HRP Bundle | sc-545727 | 200 µg Ab; 20 µg BP | $361.00 |