RFX1 Antibody (H-11): sc-166468

RFX1 Antibody (H-11) is a mouse monoclonal IgG1 antibody that detects RFX1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RFX1 is a crucial transcription factor that plays a significant role in the regulation of MHC class II genes, which are essential for the immune response. Located primarily in the nucleus, RFX1 interacts with other members of the RFX protein family, including RFX2 and RFX3, to form a complex that binds to specific enhancer elements in the promoters of various genes, including those involved in the immune response to pathogens. RFX1′s ability to activate these genes in response to signals such as interferon-γ is vital for proper immune system functioning, as this activation enhances antigen presentation to T cells, facilitating an effective immune response. Additionally, RFX1 is involved in transcriptional regulation of viral genes, such as those from hepatitis B virus, highlighting RFX1′s importance in both cellular and viral gene expression. Anti-RFX1 antibody (H-11) serves as an invaluable tool for researchers studying immune regulation and molecular mechanisms underlying gene expression in human cells.

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RFX1 Antibody (H-11) References:

1. RFX1 mediates the serum-induced immediate early response of Id2 gene expression.  |  Wang, KR., et al. 2007. J Biol Chem. 282: 26167-77. PMID: 17630394
2. RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1.  |  Zhao, M., et al. 2010. Arthritis Res Ther. 12: R227. PMID: 21192791
3. Transcription factor RFX1 is crucial for maintenance of genome integrity in Fusarium graminearum.  |  Min, K., et al. 2014. Eukaryot Cell. 13: 427-36. PMID: 24465002
4. IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation.  |  Zhao, M., et al. 2018. Nat Commun. 9: 583. PMID: 29422534
5. RFX1 participates in doxorubicin-induced hepatitis B virus reactivation.  |  Wang, J., et al. 2018. Cancer Med. 7: 2021-2033. PMID: 29601674
6. Downregulation of RFX1 predicts poor prognosis of patients with small hepatocellular carcinoma.  |  Liu, Y., et al. 2018. Eur J Surg Oncol. 44: 1087-1093. PMID: 29764705
7. RFX1-mediated CCN3 induction that may support chondrocyte survival under starved conditions.  |  Mizukawa, T., et al. 2021. J Cell Physiol. 236: 6884-6896. PMID: 33655492
8. RXR agonist, Bexarotene, effectively reduces drug resistance via regulation of RFX1 in embryonic carcinoma cells.  |  Issac, J., et al. 2023. Biochim Biophys Acta Mol Cell Res. 1870: 119510. PMID: 37301270
9. Hypoxia-induced exosomes facilitate lung pre-metastatic niche formation in hepatocellular carcinoma through the miR-4508-RFX1-IL17A-p38 MAPK-NF-κB pathway.  |  Jia, W., et al. 2023. Int J Biol Sci. 19: 4744-4762. PMID: 37781522
10. RFX1 regulates foam cell formation and atherosclerosis by mediating CD36 expression.  |  Yang, S., et al. 2024. Int Immunopharmacol. 130: 111751. PMID: 38402833

The preferred RFX1 antibody is RFX1 Antibody (F-6): sc-374270.