RBM38 Antibody (A-8): sc-365898

RBM38 Antibody (A-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects RBM38 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-RBM38 antibody (A-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RBM38, also known as RNA-binding protein 38 or RNPC1, plays a crucial role in regulating cell cycle and mRNA splicing. RBM38 is primarily located in cytosol and nucleus and exists as two alternatively spliced isoforms, RNPC1a and RNPC1b, consisting of 239 and 121 amino acids, respectively. RBM38 maintains transcript stability at the 3′-untranslated region of p21, a key regulator of cell cycle progression at S phase, thereby inducing cell cycle arrest in G1 phase independently of p53 expression. RBM38 is also involved in regulating FGFR2 expression, highlighting RBM38′s role in cellular processes that can influence tumorigenesis. One RNA recognition motif (RRM) domain in RBM38 facilitates function as an mRNA splicing factor, making RBM38 essential for proper gene expression and cellular homeostasis.

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RBM38 Antibody (A-8) References:

1. Signaling to p53: breaking the posttranslational modification code.  |  Appella, E. and Anderson, CW. 2000. Pathol Biol (Paris). 48: 227-45. PMID: 10858956
2. Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX.  |  Krackhardt, AM., et al. 2002. Blood. 100: 2123-31. PMID: 12200376
3. Regulation of the specific DNA binding function of p53.  |  Hupp, TR., et al. 1992. Cell. 71: 875-86. PMID: 1423635
4. RNPC1, an RNA-binding protein and a target of the p53 family, is required for maintaining the stability of the basal and stress-induced p21 transcript.  |  Shu, L., et al. 2006. Genes Dev. 20: 2961-72. PMID: 17050675
5. ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing.  |  Warzecha, CC., et al. 2009. Mol Cell. 33: 591-601. PMID: 19285943
6. Isolation of human-p53-specific monoclonal antibodies and their use in the studies of human p53 expression.  |  Banks, L., et al. 1986. Eur J Biochem. 159: 529-34. PMID: 2428616
7. The Rbm38-p63 feedback loop is critical for tumor suppression and longevity.  |  Jiang, Y., et al. 2018. Oncogene. 37: 2863-2872. PMID: 29520104
8. RBM38 plays a tumor-suppressor role via stabilizing the p53-mdm2 loop function in hepatocellular carcinoma.  |  Ye, J., et al. 2018. J Exp Clin Cancer Res. 37: 212. PMID: 30176896
9. Structural basis for mRNA recognition by human RBM38.  |  Qian, K., et al. 2020. Biochem J. 477: 161-172. PMID: 31860021
10. RNA-Binding motif protein 38 (RBM38) mediates HBV pgRNA packaging into the nucleocapsid.  |  Yao, Y., et al. 2022. Antiviral Res. 198: 105249. PMID: 35041910
11. Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.  |  Cho, KW., et al. 2023. Circulation. 147: 1823-1842. PMID: 37158107
12. RBM38 Reverses Sorafenib Resistance in Hepatocellular Carcinoma Cells by Combining and Promoting lncRNA-GAS5.  |  Gao, X., et al. 2023. Cancers (Basel). 15: PMID: 37296859

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RBM38 Antibody (A-8) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-RBM38 Antibody (A-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RBM38 Antibody (A-8) Specifications

Alternate Product Name: RBM38

Product Clone Name: A-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 131-157

Epitope Target: RBM38

Epitope Species: human

Product Reactivity/Detection: RBM38

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for RBM38 Antibody (A-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred RBM24/38 antibody is RBM24/38 Antibody (G-6): sc-393124.