RBM24/38 Antibody (G-6): sc-393124

RBM24/38 Antibody (G-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects RBM24/38 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RBM24/38 (G-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RBM24/38 protein, also known as RNA-binding protein 38 or RNPC1, plays a crucial role in regulating cell cycle, particularly in response to DNA damage. RBM24/38 is primarily located in the cytosol and nucleus and exists as two alternatively spliced isoforms, RNPC1a and RNPC1b, which consist of 239 and 121 amino acids, respectively. RBM24/38 maintains transcript stability at the 3′-untranslated region of p21, a key regulator of cell cycle progression at the S phase. By stabilizing p21 mRNA, RBM24/38 facilitates cell cycle arrest in the G1 phase, thereby preventing unregulated cell division that can lead to tumor formation. Additionally, RBM24/38 functions as an mRNA splicing factor, influencing the expression of fibroblast growth factor receptor 2 (FGFR2), which is vital for various cellular processes, including proliferation and differentiation. The presence of one RNA recognition motif (RRM) domain in RBM24/38 underscores its role in RNA binding and regulation, making anti-RBM24/38 antibody (G-6) an essential tool for studying cell cycle dynamics and RNA processing in cancer research and other biological applications.

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RBM24/38 Antibody (G-6) References:

1. Signaling to p53: breaking the posttranslational modification code.  |  Appella, E. and Anderson, CW. 2000. Pathol Biol (Paris). 48: 227-45. PMID: 10858956
2. Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX.  |  Krackhardt, AM., et al. 2002. Blood. 100: 2123-31. PMID: 12200376
3. Regulation of the specific DNA binding function of p53.  |  Hupp, TR., et al. 1992. Cell. 71: 875-86. PMID: 1423635
4. RNPC1, an RNA-binding protein and a target of the p53 family, is required for maintaining the stability of the basal and stress-induced p21 transcript.  |  Shu, L., et al. 2006. Genes Dev. 20: 2961-72. PMID: 17050675
5. ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing.  |  Warzecha, CC., et al. 2009. Mol Cell. 33: 591-601. PMID: 19285943
6. RNA-binding proteins Rbm38 and Rbm24 regulate myogenic differentiation via p21-dependent and -independent regulatory pathways.  |  Miyamoto, S., et al. 2009. Genes Cells. 14: 1241-52. PMID: 19817877
7. Isolation of human-p53-specific monoclonal antibodies and their use in the studies of human p53 expression.  |  Banks, L., et al. 1986. Eur J Biochem. 159: 529-34. PMID: 2428616
8. Characterization of the duck (Anas platyrhynchos) Rbm24 and Rbm38 genes and their expression profiles in myoblast and skeletal muscle tissues.  |  Sun, W., et al. 2016. Comp Biochem Physiol B Biochem Mol Biol. 198: 27-36. PMID: 27040525
9. Alternative Splicing of Cdh23 Exon 68 Is Regulated by RBM24, RBM38, and PTBP1.  |  Li, N., et al. 2020. Neural Plast. 2020: 8898811. PMID: 32774357
10. RNA-Binding Protein Rbm24 as a Multifaceted Post-Transcriptional Regulator of Embryonic Lineage Differentiation and Cellular Homeostasis.  |  Grifone, R., et al. 2020. Cells. 9: PMID: 32806768
11. Survivin Expression Is Differentially Regulated by a Selective Cross-talk between RBM38 and miRNAs let-7b or miR-203a.  |  Lucchesi, CA., et al. 2021. Cancer Res. 81: 1827-1839. PMID: 33472892
12. Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.  |  Cho, KW., et al. 2023. Circulation. 147: 1823-1842. PMID: 37158107

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RBM24/38 Antibody (G-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-RBM24/38 Antibody (G-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RBM24/38 Antibody (G-6) Specifications

Alternate Product Name: RBM24/38

Product Clone Name: G-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 26-86

Epitope Target: RBM38

Epitope Species: human

Product Reactivity/Detection: RBM24 and RBM38

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for RBM24/38 Antibody (G-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred RBM38 antibody is RBM38 Antibody (A-8): sc-365898.