Ral GDS Antibody (C-11): sc-393809
- Ral GDS Antibody (C-11) is a mouse monoclonal IgG1 κ Ral GDS antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 42-110 mapping near the N-terminus of Ral GDS of human origin
- Ral GDS Antibody (C-11) is recommended for detection of Ral GDS of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Ral GDS Antibody (C-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Ral GDS Antibody (C-11) for WB applications. These reagents are now offered in bundles with Ral GDS Antibody (C-11) (see ordering information below).
QUICK LINKS
SEE ALSO...
Ral GDS Antibody (C-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects Ral GDS of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Ral GDS antibody (C-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Ral GDS functions as a guanine nucleotide exchange factor, specifically activating Ral A and Ral B proteins, which belong to a distinct subfamily of Ras-related GTPases. Ral GDS contributes to cell proliferation, differentiation, and survival through signaling pathway regulation. Unlike Ras counterparts, Ral GDS doesn′t induce transformed foci when activated, suggesting a unique regulatory mechanism. Ral GDS interacts with downstream targets like Ral BP-1, containing a Rho-GTPase-activating domain that preferentially binds to Cdc42, demonstrating complex signaling pathway connections. Ral GDS mediates phospholipase D activation through Ras/Ral signaling, highlighting significance in cellular signaling and potential roles in cancer biology and therapeutic targeting.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ral GDS Antibody (C-11) References:
- Involvement of Ral GTPase in v-Src-induced phospholipase D activation. | Jiang, H., et al. 1995. Nature. 378: 409-12. PMID: 7477381
- Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases. | Cantor, SB., et al. 1995. Mol Cell Biol. 15: 4578-84. PMID: 7623849
- Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. | Jullien-Flores, V., et al. 1995. J Biol Chem. 270: 22473-7. PMID: 7673236
- Isolation of cDNA clones and tissue expression of rat ral A and ral B GTP-binding proteins. | Wildey, GM., et al. 1993. Biochem Biophys Res Commun. 194: 552-9. PMID: 7687439
- Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap. | Spaargaren, M. and Bischoff, JR. 1994. Proc Natl Acad Sci U S A. 91: 12609-13. PMID: 7809086
- Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator. | Hofer, F., et al. 1994. Proc Natl Acad Sci U S A. 91: 11089-93. PMID: 7972015
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ral GDS Antibody (C-11) | sc-393809 | 200 µg/ml | $316.00 | |||
Ral GDS Antibody (C-11): m-IgG Fc BP-HRP Bundle | sc-530585 | 200 µg Ab; 10 µg BP | $354.00 | |||
Ral GDS Antibody (C-11): m-IgGκ BP-HRP Bundle | sc-524095 | 200 µg Ab, 40 µg BP | $354.00 | |||
Ral GDS Antibody (C-11): m-IgG1 BP-HRP Bundle | sc-544145 | 200 µg Ab; 20 µg BP | $354.00 | |||
Ral GDS Antibody (C-11) AC | sc-393809 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Ral GDS Antibody (C-11) HRP | sc-393809 HRP | 200 µg/ml | $316.00 | |||
Ral GDS Antibody (C-11) FITC | sc-393809 FITC | 200 µg/ml | $330.00 | |||
Ral GDS Antibody (C-11) PE | sc-393809 PE | 200 µg/ml | $343.00 | |||
Ral GDS Antibody (C-11) Alexa Fluor® 488 | sc-393809 AF488 | 200 µg/ml | $357.00 | |||
Ral GDS Antibody (C-11) Alexa Fluor® 546 | sc-393809 AF546 | 200 µg/ml | $357.00 | |||
Ral GDS Antibody (C-11) Alexa Fluor® 594 | sc-393809 AF594 | 200 µg/ml | $357.00 | |||
Ral GDS Antibody (C-11) Alexa Fluor® 647 | sc-393809 AF647 | 200 µg/ml | $357.00 | |||
Ral GDS Antibody (C-11) Alexa Fluor® 680 | sc-393809 AF680 | 200 µg/ml | $357.00 | |||
Ral GDS Antibody (C-11) Alexa Fluor® 790 | sc-393809 AF790 | 200 µg/ml | $357.00 |