RAGE Antibody (A11): sc-80652
- RAGE Antibody (A11) is a mouse monoclonal IgG2a κ, cited in 30 publications, provided at 200 µg/ml
- raised against a truncated extracellular domain of RAGE of human origin
- Anti-RAGE Antibody (A11) is recommended for detection of natural and recombinant RAGE of mouse, rat and human origin by WB, IP, IF and IHC(P); also reactive with additional species, including bovine
- Anti-RAGE Antibody (A11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RAGE Antibody (A11) for WB and IHC(P) applications. These reagents are now offered in bundles with RAGE Antibody (A11) (see ordering information below).
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RAGE Antibody (A11) is a mouse monoclonal IgG2a kappa kappa light chain antibody engineered to target the truncated extracellular domain of the human Receptor for Advanced Glycation End Products (RAGE). RAGE is a type I membrane protein characterized by its distinctive structure, which includes a single V-type immunoglobulin domain followed by two C-type immunoglobulin domains in its extracellular region, a transmembrane domain, and a short cytoplasmic tail. This structural configuration facilitates the binding of various ligands, including advanced glycation end products (AGEs), S100 proteins, and high-mobility group box 1 (HMGB1), enabling RAGE to initiate and propagate diverse intracellular signaling pathways. The extracellular domains of RAGE are essential for ligand recognition and binding, which triggers downstream effects such as the activation of NF-κB and the production of reactive oxygen species, ultimately influencing inflammatory responses, cellular proliferation, and apoptosis. The precise structural features of RAGE also allow for dimerization and interaction with other membrane proteins, enhancing RAGE′s role in cellular communication and signal transduction. Anti-RAGE antibody (A11) is optimized for the detection of natural and recombinant RAGE from mouse, rat, and human origins through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Additionally, RAGE monoclonal antibody (A11) exhibits reactivity with other species such as bovine, broadening its utility in diverse research settings. By targeting the extracellular domain, anti-RAGE antibody (A11) effectively facilitates the study of RAGE′s structural-functional relationships and its involvement in pathological conditions like diabetes, vascular disorders, and amyloidosis. RAGE (A11) antibody is an indispensable tool for researchers aiming to elucidate the mechanistic roles of RAGE in disease progression and to develop potential therapeutic interventions targeting RAGE-mediated pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RAGE Antibody (A11) | sc-80652 | 200 µg/ml | $322.00 | |||
RAGE Antibody (A11): m-IgG Fc BP-HRP Bundle | sc-528697 | 200 µg Ab; 10 µg BP | $361.00 | |||
RAGE Antibody (A11): m-IgGκ BP-HRP Bundle | sc-521158 | 200 µg Ab, 40 µg BP | $361.00 | |||
RAGE Antibody (A11): m-IgG2a BP-HRP Bundle | sc-547152 | 200 µg Ab; 10 µg BP | $361.00 | |||
RAGE Antibody (A11) AC | sc-80652 AC | 500 µg/ml, 25% agarose | $424.00 | |||
RAGE Antibody (A11) HRP | sc-80652 HRP | 200 µg/ml | $322.00 | |||
RAGE Antibody (A11) FITC | sc-80652 FITC | 200 µg/ml | $336.00 | |||
RAGE Antibody (A11) PE | sc-80652 PE | 200 µg/ml | $349.00 | |||
RAGE Antibody (A11) Alexa Fluor® 488 | sc-80652 AF488 | 200 µg/ml | $364.00 | |||
RAGE Antibody (A11) Alexa Fluor® 546 | sc-80652 AF546 | 200 µg/ml | $364.00 | |||
RAGE Antibody (A11) Alexa Fluor® 594 | sc-80652 AF594 | 200 µg/ml | $364.00 | |||
RAGE Antibody (A11) Alexa Fluor® 647 | sc-80652 AF647 | 200 µg/ml | $364.00 | |||
RAGE Antibody (A11) Alexa Fluor® 680 | sc-80652 AF680 | 200 µg/ml | $364.00 | |||
RAGE Antibody (A11) Alexa Fluor® 790 | sc-80652 AF790 | 200 µg/ml | $364.00 |