Rad51D Antibody (5A8/4): sc-53431

Rad51D Antibody (5A8/4) is a mouse monoclonal IgG1 kappa light chain antibody engineered to detect Rad51D protein from mouse, rat, and human origins with exceptional precision in applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). anti-Rad51D antibody (5A8/4) is raised against the full-length recombinant human Rad51D protein, ensuring robust and specific binding to the target antigen. Rad51D, also called TRAD, R51H3, Rad51l3, and Trad-d5, is a vital member of the Rad52 family of proteins, playing a crucial role in homologous recombination repair (HRR) of DNA double-strand breaks, which is essential for maintaining genomic stability and preventing mutations that could lead to cancerous transformations. Structurally, Rad51D interacts closely with other Rad51 paralogs, including Rad51C, XRCC2, and XRCC3, forming multi-protein complexes essential for accurate repair of DNA damage. These interactions facilitate formation and stabilization of Rad51 nucleoprotein filaments on DNA, promoting search for homology and strand invasion steps necessary for effective DNA repair. Rad51D′s ability to interact with these specific proteins is critical for coordinating cellular response to DNA damage, ensuring repair processes are executed correctly to prevent genomic instability, a hallmark of many cancers. Additionally, Rad51D interacts with BRCA1 and BRCA2, influencing their localization and function within cells, which further underscores importance in DNA damage response and tumor suppression. Rad51D (5A8/4) monoclonal antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® dyes, providing versatile options for diverse experimental setups. By utilizing Rad51D (5A8/4) antibody, researchers can gain deeper insights into intricate network of protein interactions involved in DNA repair mechanisms, role of Rad51D in maintaining genomic integrity, and implications in cancer development and therapeutic interventions, highlighting importance in advanced biomedical research and diagnostics.

The preferred Rad51D antibody is Rad51D Antibody (C-1): sc-398819.