PXK Antibody (D-6): sc-377077
- PXK Antibody (D-6) is a mouse monoclonal IgG2b κ PXK antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 375-407 within an internal region of PXK of human origin
- PXK Antibody (D-6) is recommended for detection of PXK of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-PXK Antibody (D-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PXK Antibody (D-6) for WB and IHC(P) applications. These reagents are now offered in bundles with PXK Antibody (D-6) (see ordering information below).
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SEE ALSO...
PXK Antibody (D-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects PXK protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). PXK (D-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PXK, also known as PX domain containing serine/threonine kinase, FLJ20335, MONaKA, or Modulator of Na+/K+-ATPase, is a 578 amino acid protein that plays a crucial role in regulating synaptic transmission and electrical excitability in the brain by interacting with Na+/K+-ATPase subunits β1 and β3. This interaction is vital for maintaining cellular ion homeostasis and proper neuronal function. While PXK belongs to the protein kinase superfamily, PXK lacks catalytic kinase activity, highlighting a unique role in cellular signaling pathways. PXK predominantly localizes to the cell membrane, peripheral membrane, and cytoplasm, with occasional association with the plasma membrane, and exists in seven known isoforms. Isoform 1 shows high expression in tissues such as the spleen, testis, brain, and skeletal muscle, but remains absent in the heart. The diverse expression and functional implications of PXK underscore its importance in various physiological processes, making anti-PXK antibody (D-6) an essential tool for researchers studying its role in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PXK Antibody (D-6) References:
- MONaKA, a novel modulator of the plasma membrane Na,K-ATPase. | Mao, H., et al. 2005. J Neurosci. 25: 7934-43. PMID: 16135750
- Expression pattern and subcellular localization of five splice isoforms of human PXK. | Zou, X., et al. 2005. Int J Mol Med. 16: 701-7. PMID: 16142408
- Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. | , ., et al. 2008. Nat Genet. 40: 204-10. PMID: 18204446
- Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese. | Yang, W., et al. 2009. Genes Immun. 10: 219-26. PMID: 19225526
- Four distinct cyclin-dependent kinases phosphorylate histone H1 at all of its growth-related phosphorylation sites. | Swank, RA., et al. 1997. Biochemistry. 36: 13761-8. PMID: 9374852
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PXK Antibody (D-6) | sc-377077 | 200 µg/ml | $322.00 | |||
PXK Antibody (D-6): m-IgGκ BP-HRP Bundle | sc-523175 | 200 µg Ab, 40 µg BP | $361.00 | |||
PXK Antibody (D-6): m-IgG2b BP-HRP Bundle | sc-549092 | 200 µg Ab; 10 µg BP | $361.00 | |||
PXK Antibody (D-6) AC | sc-377077 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PXK Antibody (D-6) HRP | sc-377077 HRP | 200 µg/ml | $322.00 | |||
PXK Antibody (D-6) FITC | sc-377077 FITC | 200 µg/ml | $336.00 | |||
PXK Antibody (D-6) PE | sc-377077 PE | 200 µg/ml | $349.00 | |||
PXK Antibody (D-6) Alexa Fluor® 488 | sc-377077 AF488 | 200 µg/ml | $364.00 | |||
PXK Antibody (D-6) Alexa Fluor® 546 | sc-377077 AF546 | 200 µg/ml | $364.00 | |||
PXK Antibody (D-6) Alexa Fluor® 594 | sc-377077 AF594 | 200 µg/ml | $364.00 | |||
PXK Antibody (D-6) Alexa Fluor® 647 | sc-377077 AF647 | 200 µg/ml | $364.00 | |||
PXK Antibody (D-6) Alexa Fluor® 680 | sc-377077 AF680 | 200 µg/ml | $364.00 | |||
PXK Antibody (D-6) Alexa Fluor® 790 | sc-377077 AF790 | 200 µg/ml | $364.00 | |||
PXK (D-6) Neutralizing Peptide | sc-377077 P | 100 µg/0.5 ml | $69.00 |