PXK Activators
PXK activators encompass a diverse array of chemical compounds that indirectly bolster the functional activity of PXK by targeting specific signaling pathways within the cellular milieu. Compounds such as Forskolin and IBMX excel in elevating intracellular cAMP levels, leading to the activation of PKA-a kinase capable of phosphorylating substrates that could enhance PXK's activity or modulate signaling pathways to favor PXK's role in the cell. Similarly, PMA functions as an activator of PKC, potentially resulting in the phosphorylation of PXK or modifying the signaling environment to promote PXK's activity. EGCG and Genistein, through their kinase inhibition, reduce competitive signaling noise, creating a more favorable context for PXK's signaling pathways to be accentuated. The lipid signaling molecule sphingosine-1-phosphate further enriches this regulatory ensemble by binding to its receptors, possibly interlinking with signaling cascades that amplify PXK's role.
Thapsigargin shifts the signaling landscape by disrupting calcium homeostasis, which could lead to the enhancement of PXK activity. A23187, a calcium ionophore, escalates intracellular calcium levels, thus activating calcium-dependent signaling routes that could fortify the activity of PXK. These PXK activators, via their targeted effects on cellular signaling, facilitate the accentuation of PXK's function without necessitating an upsurge in its expression or direct stimulation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP levels, which activates PKA. PKA can phosphorylate various proteins and targets within the cell, potentially enhancing the activity of PXK by phosphorylation or by creating an environment that favors PXK activity in signal transduction. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC), which is involved in various signaling pathways. Activation of PKC can lead to the phosphorylation and activation of PXK if PXK is a substrate of PKC or if PKC phosphorylates molecules that interact with PXK. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known to inhibit certain types of kinases. By inhibiting these kinases, EGCG may reduce competitive signaling and allow PXK pathways to be more active, thus enhancing PXK activity in its specific signaling roles. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
This lipid signaling molecule can activate sphingosine-1-phosphate receptors, which may be part of signaling cascades that include PXK, resulting in enhanced PXK activity through these pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, leading to increased cAMP levels. The elevated cAMP can activate PKA, which may then enhance PXK activity through phosphorylation or modulation of PXK-related signaling pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin raises intracellular calcium levels by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). Increased intracellular calcium can activate calcium-dependent signaling pathways, potentially enhancing PXK activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, thereby activating calcium-dependent signaling pathways which could enhance PXK activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor, which may enhance PXK activity by reducing competitive tyrosine kinase signaling, potentially allowing PXK to have a more prominent role in cellular signaling processes. | ||||||