PTTG Antibody (C-2): sc-398471

PTTG Antibody (C-2) is a mouse monoclonal IgG2a light chain antibody that detects pituitary tumor transforming gene (PTTG) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PTTG plays a crucial role in cell cycle regulation by acting as an anaphase inhibitor, specifically regulating the separin Esp1, which is essential for chromatid separation during mitosis. This function ensures proper chromosome segregation, preventing aneuploidy, which can lead to tumorigenesis. PTTG is predominantly localized in the cytoplasm but is also found in the nucleus, highlighting its dual role in both cytoplasmic and nuclear processes. The overexpression of PTTG in various cancers suggests that dysregulation may contribute to chromosomal instability, a hallmark of cancer progression. Anti-PTTG antibody (C-2) serves as an invaluable tool for researchers studying cell cycle control mechanisms and PTTG′s implications in oncogenesis, providing insights into potential therapeutic targets for cancer treatment.

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PTTG Antibody (C-2) References:

1. Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG).  |  Kakar, SS. 1999. Gene. 240: 317-24. PMID: 10580151
2. PTTG and cancer.  |  Hamid, T. and Kakar, SS. 2003. Histol Histopathol. 18: 245-51. PMID: 12507303
3. The relationship between pituitary tumour transforming gene (PTTG) expression and in vitro hormone and vascular endothelial growth factor (VEGF) secretion from human pituitary adenomas.  |  Hunter, JA., et al. 2003. Eur J Endocrinol. 148: 203-11. PMID: 12590639
4. A potential role for PTTG/securin in the developing human fetal brain.  |  Boelaert, K., et al. 2003. FASEB J. 17: 1631-9. PMID: 12958169
5. Characterization of the role of Sp1 and NF-Y in differential regulation of PTTG/securin expression in tumor cells.  |  Clem, AL., et al. 2003. Gene. 322: 113-21. PMID: 14644503
6. Inhibitory effects of anti-sense PTTG on malignant phenotype of human ovarian carcinoma cell line SK-OV-3.  |  Chen, G., et al. 2004. J Huazhong Univ Sci Technolog Med Sci. 24: 369-72. PMID: 15587401
7. Insulin and IGF-1 regulate the expression of the pituitary tumor transforming gene (PTTG) in breast tumor cells.  |  Thompson, AD. and Kakar, SS. 2005. FEBS Lett. 579: 3195-200. PMID: 15922332
8. [Expression and clinical significance of PTTG and b-FGF in acute leukemia].  |  Cong, J., et al. 2005. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 13: 951-3. PMID: 16403257
9. Pituitary tumor transforming gene (PTTG) stimulates thyroid cell proliferation via a vascular endothelial growth factor/kinase insert domain receptor/inhibitor of DNA binding-3 autocrine pathway.  |  Kim, DS., et al. 2006. J Clin Endocrinol Metab. 91: 4603-11. PMID: 16926250
10. Regulation of pituitary tumor transforming gene (PTTG) expression and phosphorylation in thyroid cells.  |  Lewy, GD., et al. 2013. Endocrinology. 154: 4408-22. PMID: 23867215

The preferred PTTG antibody is PTTG Antibody (DCS-280): sc-56207.