PTTG Antibody (C-2): sc-398471
- PTTG Antibody (C-2) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-160 of PTTG of human origin
- recommended for detection of PTTG of mouse, rat and human origin, and PTTG2 of human origin by WB, IP, IF and ELISA
- See PTTG (DCS-280): sc-56207 for PTTG antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PTTG Antibody (C-2) for WB applications. These reagents are now offered in bundles with PTTG Antibody (C-2) (see ordering information below).
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SEE ALSO...
PTTG Antibody (C-2) is a mouse monoclonal IgG2a light chain antibody that detects pituitary tumor transforming gene (PTTG) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PTTG plays a crucial role in cell cycle regulation by acting as an anaphase inhibitor, specifically regulating the separin Esp1, which is essential for chromatid separation during mitosis. This function ensures proper chromosome segregation, preventing aneuploidy, which can lead to tumorigenesis. PTTG is predominantly localized in the cytoplasm but is also found in the nucleus, highlighting its dual role in both cytoplasmic and nuclear processes. The overexpression of PTTG in various cancers suggests that dysregulation may contribute to chromosomal instability, a hallmark of cancer progression. Anti-PTTG antibody (C-2) serves as an invaluable tool for researchers studying cell cycle control mechanisms and PTTG′s implications in oncogenesis, providing insights into potential therapeutic targets for cancer treatment.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTTG Antibody (C-2) | sc-398471 | 200 µg/ml | $322.00 | |||
PTTG Antibody (C-2): m-IgG Fc BP-HRP Bundle | sc-538450 | 200 µg Ab; 10 µg BP | $361.00 | |||
PTTG Antibody (C-2): m-IgGκ BP-HRP Bundle | sc-536068 | 200 µg Ab; 40 µg BP | $361.00 | |||
PTTG Antibody (C-2): m-IgG2a BP-HRP Bundle | sc-548307 | 200 µg Ab; 10 µg BP | $361.00 |