PTTG Inhibitors
PTTG (Pituitary Tumor-Transforming Gene) inhibitors are a class of chemical compounds that specifically target and inhibit the activity of the PTTG protein. PTTG is a critical protein involved in the regulation of cell division and is known to be overexpressed in various types of cancer, including pituitary tumors, as well as non-neoplastic conditions. The development of PTTG inhibitors stems from the recognition of the protein's role in promoting uncontrolled cell proliferation and tumorigenesis. These inhibitors are designed to interfere with PTTG's functions, ultimately aiming to halt or slow down the abnormal growth of cells associated with various diseases.
Structurally, PTTG inhibitors can vary widely, but they typically work by binding to the PTTG protein or its associated molecular pathways. By doing so, they disrupt the protein's normal function, which includes regulating the cell cycle and promoting cell division. PTTG inhibitors are researched extensively in the context of basic science, with the goal of understanding their mechanisms of action and for modulating cellular processes. While their exact mechanisms may vary, the overarching objective of PTTG inhibitors is to offer a means of controlling cell proliferation.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol may downregulate PTTG expression through its antioxidant and anti-inflammatory properties, potentially disrupting pathways that contribute to the overexpression of PTTG. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, could inhibit PTTG expression by modulating signaling pathways involved in cell proliferation and apoptosis, thereby contributing to cell cycle regulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to suppress PTTG expression, possibly through its anti-inflammatory and anti-cancer properties, which may disrupt the cellular environment that favors PTTG overexpression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane may reduce PTTG levels by inducing phase II detoxification enzymes, leading to the clearance of reactive oxygen species and other factors that could promote PTTG expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone, might inhibit PTTG expression by modulating estrogen receptor signaling and influencing pathways associated with cell growth and differentiation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a major catechin in green tea, could suppress PTTG expression through its antioxidant properties and by interfering with signaling pathways involved in cell proliferation. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
I3C may downregulate PTTG expression as a result of its ability to modulate estrogen metabolism, potentially impacting pathways related to cell cycle control and tumor suppression. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $55.00 $114.00 $206.00 $714.00 | 6 | |
Silybin, found in milk thistle, might reduce PTTG levels through its hepatoprotective and anti-cancer properties, which could alter the cellular conditions that favor PTTG expression. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Ellagic acid may inhibit PTTG expression by exerting anti-inflammatory and anti-cancer effects, potentially disrupting cellular pathways that contribute to PTTG overexpression. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine might suppress PTTG expression through its anti-inflammatory and anti-cancer activities, influencing signaling pathways related to cell proliferation and apoptosis. | ||||||