PTPµ Antibody (BK2): sc-33651
- PTPµ Antibody (BK2) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- raised against a synthetic peptide from the extracellular segment of PTPμ
- recommended for detection of full length PTPµ (200 kDa) and extracellular, E-subunit (100 kDa) of mouse, rat, human and Xenopus origin by WB, IP and IF; also reactive with additional species, including bovine
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PTPµ Antibody (BK2) for WB applications. These reagents are now offered in bundles with PTPµ Antibody (BK2) (see ordering information below).
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PTPµ Antibody (BK2) is a mouse monoclonal IgG2a antibody that detects PTPµ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). PTPµ, a member of the protein tyrosine phosphatase family, is primarily localized to the cell membrane and plays a crucial role in cell adhesion and signaling processes. Anti-PTPµ antibody (BK2) recognizes a unique structure including a conserved amino-terminal MAM domain, which is essential for homophilic binding, allowing PTPµ to interact with itself and potentially regulate the assembly and disassembly of cadherin/catenin complexes at cell junctions. This function is vital for maintaining tissue integrity and facilitating communication between cells, which is particularly important during development and in the context of cancer progression. Dysregulation of PTPµ has been implicated in various diseases, making PTPµ a significant target for research into therapeutic interventions. PTPµ monoclonal antibody (BK2) serves as an invaluable tool for studying the dynamics of cell adhesion and signaling pathways in various biological contexts.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PTPµ Antibody (BK2) References:
- The dynamic interplay between a PTK (Kit) and a PTP (Shp2) in hematopoietic stem and progenitor cells. | Zhu, HH. and Feng, GS. 2011. Cell Cycle. 10: 2241-2. PMID: 21701261
- Identification of receptor-type protein tyrosine phosphatase μ as a new marker for osteocytes. | de Rooij, KE., et al. 2015. Histochem Cell Biol. 144: 1-11. PMID: 25850409
- TC-PTP and PTP1B: Regulating JAK-STAT signaling, controlling lymphoid malignancies. | Pike, KA. and Tremblay, ML. 2016. Cytokine. 82: 52-7. PMID: 26817397
- β1,6 GlcNAc branches-modified protein tyrosine phosphatase Mu attenuates its tyrosine phosphatase activity and promotes glioma cell migration through PLCγ-PKC pathways. | Gao, Y., et al. 2018. Biochem Biophys Res Commun. 505: 569-577. PMID: 30274773
- VE-PTP inhibition elicits eNOS phosphorylation to blunt endothelial dysfunction and hypertension in diabetes. | Siragusa, M., et al. 2021. Cardiovasc Res. 117: 1546-1556. PMID: 32653904
- Exploring protein tyrosine phosphatases (PTP) and PTP-1B inhibitors in management of diabetes mellitus. | Behl, T., et al. 2022. Biomed Pharmacother. 153: 113405. PMID: 36076528
- Shear stress control of vascular leaks and atheromas through Tie2 activation by VE-PTP sequestration. | Shirakura, K., et al. 2023. EMBO Mol Med. 15: e16128. PMID: 36740996
- Activin A Limits VEGF-Induced Permeability via VE-PTP. | Baccouche, B., et al. 2023. Int J Mol Sci. 24: PMID: 37240047
- A novel binding pocket in the D2 domain of protein tyrosine phosphatase mu (PTPmu) guides AI screen to identify small molecules that modulate tumour cell adhesion, growth and migration. | Molyneaux, K., et al. 2023. J Cell Mol Med. 27: 3553-3564. PMID: 37860940
- Discovery of a selective TC-PTP degrader for cancer immunotherapy. | Miao, J., et al. 2023. Chem Sci. 14: 12606-12614. PMID: 38020389
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTPµ Antibody (BK2) | sc-33651 | 200 µg/ml | $316.00 | |||
PTPµ Antibody (BK2): m-IgG Fc BP-HRP Bundle | sc-536768 | 200 µg Ab; 10 µg BP | $354.00 | |||
PTPµ Antibody (BK2): m-IgGκ BP-HRP Bundle | sc-533932 | 200 µg Ab; 40 µg BP | $354.00 | |||
PTPµ Antibody (BK2): m-IgG2a BP-HRP Bundle | sc-547866 | 200 µg Ab; 10 µg BP | $354.00 |