PTP22 Antibody (G-3): sc-376349

PTP22 Antibody (G-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects PTP22 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PTP22 antibody (G-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The protein tyrosine phosphatase PTPN22, also known as LYP or PEP, plays a critical role in immune regulation and is associated with the risk of developing several autoimmune diseases, including type 1 diabetes and rheumatoid arthritis. Located primarily in hematopoietic cells, PTPN22 is essential for modulating T cell activation, and genetic variants can significantly impact immune responses. Notably, a specific missense single nucleotide polymorphism in PTPN22 leads to a variant that disrupts the proline-rich motif crucial for interaction with the Src homology-3 domain of cytoplasmic tyrosine kinase (CSK). This disruption may alter normal regulatory functions of both proteins, potentially enhancing T cell activation and contributing to autoimmune pathology. The presence of the risk allele in approximately 17% of the Caucasian population and 28% of those with rheumatoid arthritis underscores PTPN22′s importance in understanding autoimmune disease mechanisms and developing targeted therapies.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

PTP22 Antibody (G-3) References:

1. Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp.  |  Cohen, S., et al. 1999. Blood. 93: 2013-24. PMID: 10068674
2. PTPN22 and autoimmune disease.  |  Siminovitch, KA. 2004. Nat Genet. 36: 1248-9. PMID: 15565104
3. Association of the PTPN22 locus with rheumatoid arthritis in a New Zealand Caucasian cohort.  |  Simkins, HM., et al. 2005. Arthritis Rheum. 52: 2222-5. PMID: 15986352
4. A single-nucleotide polymorphism in the gene encoding lymphoid protein tyrosine phosphatase (PTPN22) confers susceptibility to generalised vitiligo.  |  Cantón, I., et al. 2005. Genes Immun. 6: 584-7. PMID: 16015369
5. The R620W C/T polymorphism of the gene PTPN22 is associated with SLE independently of the association of PDCD1.  |  Reddy, MV., et al. 2005. Genes Immun. 6: 658-62. PMID: 16052172
6. Polymorphisms in the protein tyrosine phosphatase (PTPN22) gene is not associated with autoimmune thyroid in a large affected Tunisian family.  |  Chabchoub, G., et al. 2006. Clin Immunol. 120: 235-6. PMID: 16765647
7. Lack of association of the PTPN22 gene polymorphism R620W with systemic sclerosis.  |  Balada, E., et al. 2006. Clin Exp Rheumatol. 24: 321-4. PMID: 16870103
8. Protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene R620W variant and sporadic idiopathic hypoparathyroidism in Asian Indians.  |  Ray, D., et al. 2006. Int J Immunogenet. 33: 237-40. PMID: 16893384
9. Lymphoid-specific tyrosine phosphatase (Lyp): a potential drug target for treatment of autoimmune diseases.  |  Du, J., et al. 2014. Curr Drug Targets. 15: 335-46. PMID: 24188455
10. Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease.  |  Bottini, N. and Peterson, EJ. 2014. Annu Rev Immunol. 32: 83-119. PMID: 24364806
11. Protein tyrosine phosphatase PTPN22 negatively modulates platelet function and thrombus formation.  |  Wang, X., et al. 2022. Blood. 140: 1038-1051. PMID: 35767715
12. Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.  |  Cloutier, JF. and Veillette, A. 1996. EMBO J. 15: 4909-18. PMID: 8890164

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PTP22 Antibody (G-3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-PTP22 Antibody (G-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PTP22 Antibody (G-3) Specifications

Alternate Product Name: PTP22

Product Clone Name: G-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 368-506

Epitope Target: PTP22

Epitope Species: mouse

Product Reactivity/Detection: PTP22

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for PTP22 Antibody (G-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred PTP22 antibody is PTP22 Antibody (E-5): sc-393766.