PTP22 Activators
PTP22 activators constitute a diverse group of chemicals that intricately modulate specific signaling pathways, resulting in the enhanced functional activity of PTP22. 6-Bromoindirubin-3'-oxime, a selective GSK-3β inhibitor, activates PTP22 through the Wnt/β-catenin pathway, promoting β-catenin accumulation and subsequent transcriptional activation. Forskolin stimulates the cAMP/PKA pathway, leading to the phosphorylation of transcription factors that enhance PTP22 gene expression, showcasing a direct influence on cAMP-dependent activation. Betulinic acid, Z-Ligustilide, and Oleanolic acid activate PTP22 through the PI3K/AKT, NF-κB, and Nrf2/ARE pathways, respectively, by promoting the nuclear translocation of transcription factors that positively regulate PTP22 gene expression. Gambogic acid targets the JAK/STAT pathway, inhibiting JAK2 and reducing STAT3 phosphorylation, resulting in increased PTP22 transcription. Cantharidin activates PTP22 through the p38 MAPK pathway, while Icariin and Honokiol stimulate the ERK/MAPK and PI3K/AKT pathways, respectively, all leading to enhanced PTP22 gene expression.
Zerumbone activates PTP22 through the Wnt/β-catenin pathway by inhibiting GSK-3β, stabilizing β-catenin, and promoting its transcriptional activity. Icaritin influences PTP22 through the JNK pathway, activating JNK and enhancing PTP22 gene expression. Guggulsterone activates PTP22 through the AMPK pathway, stimulating downstream signaling events that positively regulate PTP22 gene expression. This diverse array of chemical activators showcases the intricate interplay between specific signaling pathways and PTP22 functional activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
GSK-3 Inhibitor IX enhances PTP22 functional activity by targeting the Wnt/β-catenin signaling pathway. Acting as a selective glycogen synthase kinase-3β (GSK-3β) inhibitor, this compound disrupts the degradation complex, allowing β-catenin to accumulate. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates PTP22 through the cAMP-dependent protein kinase (PKA) pathway. By stimulating adenylyl cyclase, Forskolin elevates intracellular cAMP levels, leading to PKA activation. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic acid enhances PTP22 activity by activating the PI3K/AKT pathway. This compound stimulates PI3K, leading to the phosphorylation and activation of AKT. | ||||||
Oleanolic Acid | 508-02-1 | sc-205775 sc-205775A | 100 mg 500 mg | $86.00 $302.00 | 8 | |
Oleanolic acid enhances PTP22 activity by activating the Nrf2/ARE pathway. This compound induces Nrf2 translocation to the nucleus, where it binds to the antioxidant response element (ARE) in the PTP22 promoter region. | ||||||
Gambogic Acid | 2752-65-0 | sc-200137 sc-200137A sc-200137B sc-200137C sc-200137D | 5 mg 25 mg 100 mg 500 mg 1 g | $87.00 $248.00 $427.00 $734.00 $1255.00 | 5 | |
Gambogic acid activates PTP22 by influencing the JAK/STAT pathway. This compound inhibits JAK2, leading to the downregulation of STAT3 phosphorylation. Reduced STAT3 activation results in the decreased transcriptional repression of PTP22. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $89.00 $279.00 | 6 | |
Cantharidin enhances PTP22 functional activity through the modulation of the p38 MAPK pathway. This compound activates p38 MAPK, leading to downstream signaling events that positively regulate PTP22 gene expression. | ||||||
Icariin | 489-32-7 | sc-279198 sc-279198A sc-279198B | 1 g 5 g 10 g | $145.00 $421.00 $830.00 | ||
Icariin activates PTP22 through the ERK/MAPK pathway. By promoting the phosphorylation of ERK, Icariin initiates downstream signaling events that positively regulate PTP22 gene expression. | ||||||
Honokiol | 35354-74-6 | sc-202653 sc-202653A | 10 mg 25 mg | $118.00 $178.00 | 4 | |
Honokiol activates PTP22 through the PI3K/AKT pathway. This compound stimulates PI3K, leading to the phosphorylation and activation of AKT. Activated AKT promotes the nuclear translocation of transcription factors that positively regulate PTP22 gene expression. | ||||||
Zerumbone | 471-05-6 | sc-364148 sc-364148A | 10 mg 50 mg | $112.00 $408.00 | ||
Zerumbone enhances PTP22 activity by activating the Wnt/β-catenin signaling pathway. By inhibiting GSK-3β, zerumbone stabilizes β-catenin, allowing its accumulation and translocation to the nucleus. Increased β-catenin levels positively regulate PTP22 gene expression, contributing to the functional activation of PTP22. | ||||||
Z-Guggulsterone | 39025-23-5 | sc-204414B sc-204414 sc-204414A | 5 mg 10 mg 25 mg | $193.00 $369.00 $733.00 | 28 | |
Guggulsterone activates PTP22 by influencing the AMPK pathway. This compound stimulates AMPK, leading to downstream signaling events that positively regulate PTP22 gene expression. | ||||||