PTP1B Antibody (H-9): sc-133258
- PTP1B Antibody (H-9) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 301-435 mapping at the C-terminus of PTP1B (protein tyrosine phosphatase) of human origin
- recommended for detection of PTP1B of human origin by WB, IP, IF, IHC(P) and ELISA
- See PTP1B (D-4): sc-133259 for PTP1B antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PTP1B Antibody (H-9) for WB and IHC(P) applications. These reagents are now offered in bundles with PTP1B Antibody (H-9) (see ordering information below).
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PTP1B Antibody (H-9) is a mouse monoclonal IgG1 antibody that detects PTP1B in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PTP1B, or protein tyrosine phosphatase 1B, plays a crucial role in the regulation of cellular signaling pathways by dephosphorylating tyrosine residues on target proteins, thereby influencing processes such as cell growth, differentiation, and metabolism. Anti-PTP1B antibody (H-9) recognizes a protein that modulates insulin signaling and contributes to the pathophysiology of diabetes and obesity, making PTP1B a significant target for therapeutic intervention. PTP1B is primarily located in the endoplasmic reticulum and cytosol, where PTP1B interacts with various signaling molecules, including insulin receptor substrates, to regulate their activity. PTP1B is synthesized as a 435 amino acid precursor that is subsequently cleaved to produce the active 321 amino acid enzyme, which is essential for phosphatase activity. PTP1B monoclonal antibody (H-9) serves as an invaluable tool for researchers studying the intricate mechanisms of signal transduction and the role of protein tyrosine phosphorylation in human health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTP1B Antibody (H-9) | sc-133258 | 200 µg/ml | $316.00 | |||
PTP1B Antibody (H-9): m-IgG Fc BP-HRP Bundle | sc-539876 | 200 µg Ab; 10 µg BP | $354.00 | |||
PTP1B Antibody (H-9): m-IgG1 BP-HRP Bundle | sc-541758 | 200 µg Ab; 20 µg BP | $354.00 |