PTP1B Antibody (B-9): sc-133115
- PTP1B Antibody (B-9) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 301-435 mapping at the C-terminus of PTP1B (protein tyrosine phosphatase) of human origin
- recommended for detection of PTP1B of human origin by WB, IP, IF and ELISA
- See PTP1B (D-4): sc-133259 for PTP1B antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for PTP1B Antibody (B-9) for WB applications. These reagents are now offered in bundles with PTP1B Antibody (B-9) (see ordering information below).
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PTP1B Antibody (B-9) is a mouse monoclonal IgG2b antibody that detects PTP1B in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PTP1B, or protein tyrosine phosphatase 1B, plays a crucial role in the regulation of insulin signaling and is involved in the negative regulation of various signaling pathways, making PTP1B a significant target for understanding metabolic disorders such as obesity and diabetes. PTP1B is primarily located in the endoplasmic reticulum and cytoplasm, where PTP1B interacts with various signaling molecules, thereby influencing cellular responses to growth factors and hormones. Proper localization of PTP1B is essential for function, as this ensures effective dephosphorylation of substrates, thereby modulating activity and contributing to the fine-tuning of cellular signaling networks. PTP1B is synthesized as a 435 amino acid precursor that is processed to yield the active 321 amino acid enzyme, and PTP1B activity can be regulated by post-translational modifications, which further underscores PTP1B′s importance in cellular signaling and metabolic regulation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTP1B Antibody (B-9) | sc-133115 | 200 µg/ml | $316.00 | |||
PTP1B Antibody (B-9): m-IgG Fc BP-HRP Bundle | sc-539850 | 200 µg Ab; 10 µg BP | $354.00 | |||
PTP1B Antibody (B-9): m-IgG2b BP-HRP Bundle | sc-549750 | 200 µg Ab; 10 µg BP | $354.00 |