PTP-H1 Antibody (H-6): sc-515181

PTP-H1 Antibody (H-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects PTP-H1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PTP-H1 antibody (H-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PTP-H1 plays a crucial role in cellular signaling by acting as a protein tyrosine phosphatase, essential for regulating tyrosine phosphorylation—a key mechanism in signal transduction pathways. This reversible process controls various cellular functions, including growth, differentiation, and metabolism. PTP-H1 can counteract oncogenic protein-tyrosine kinases effects, such as those in the src family, potentially reversing transformation in cancer cells. PTP-H1 shares homology with cytoskeletal-associated proteins like band 4.1, ezrin, and talin, and contains PDZ and band 4.1 domains that facilitate interactions at the cytoskeleton-membrane interface. These interactions maintain cellular architecture and signaling, highlighting PTP-H1′s importance in both normal physiology and disease states.

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PTP-H1 Antibody (H-6) References:

1. Cloning of a cDNA for a major human protein-tyrosine-phosphatase.  |  Chernoff, J., et al. 1990. Proc Natl Acad Sci U S A. 87: 2735-9. PMID: 2157211
2. Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis.  |  Morla, AO., et al. 1989. Cell. 58: 193-203. PMID: 2473839
3. Phosphotyrosyl protein phosphatases.  |  Lau, KH., et al. 1989. Biochem J. 257: 23-36. PMID: 2537623
4. Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins.  |  Charbonneau, H., et al. 1989. Proc Natl Acad Sci U S A. 86: 5252-6. PMID: 2546149
5. Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis.  |  Gould, KL. and Nurse, P. 1989. Nature. 342: 39-45. PMID: 2682257
6. Purification of the major protein-tyrosine-phosphatases of human placenta.  |  Tonks, NK., et al. 1988. J Biol Chem. 263: 6722-30. PMID: 2834386
7. A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen.  |  Streuli, M., et al. 1988. J Exp Med. 168: 1523-30. PMID: 2972792
8. Protein-tyrosine kinases.  |  Hunter, T. and Cooper, JA. 1985. Annu Rev Biochem. 54: 897-930. PMID: 2992362

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PTP-H1 Antibody (H-6) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-PTP-H1 Antibody (H-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PTP-H1 Antibody (H-6) Specifications

Alternate Product Name: PTP-H1

Product Clone Name: H-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 371-510

Epitope Target: PTP-H1

Epitope Species: human

Product Reactivity/Detection: PTP-H1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for PTP-H1 Antibody (H-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin