PTEN Antibody (G-6): sc-133242

PTEN Antibody (G-6) is a mouse monoclonal IgG1 kappa light chain antibody specifically engineered to recognize the full-length PTEN protein, also known as phosphatase and tensin homolog, MMAC1, or TEP1. Anti-PTEN antibody (G-6) targets amino acids 1-403 of human PTEN and is validated for use in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA) applications across multiple species, including mouse, rat, human, and canine. PTEN is a critical tumor suppressor protein that plays a pivotal role in regulating cellular functions by dephosphorylating phosphatidylinositol (3,4,5)-trisphosphate, thereby antagonizing the PI3K/AKT signaling pathway. This regulation is essential for controlling cell growth, proliferation, and survival, making PTEN integral to maintaining cellular homeostasis and preventing uncontrolled cell division. Loss or mutation of PTEN is frequently associated with a variety of cancers, including glioblastomas, breast, kidney, and prostate cancers, highlighting PTEN′s significance in cancer biology. Additionally, PTEN is involved in various cellular processes such as apoptosis, cell migration, and genomic stability, further underscoring PTEN′s importance in preventing tumorigenesis. PTEN monoclonal antibody (G-6) enables researchers to effectively study PTEN expression and regulation in different biological contexts, facilitating advancements in understanding the molecular mechanisms underlying cancer development and progression. Anti-PTEN antibody (G-6) serves as an invaluable tool for investigating PTEN-related pathways and supports the development of targeted therapeutic strategies aimed at restoring PTEN function in cancerous cells.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PTEN Antibody (G-6) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-PTEN Antibody (G-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PTEN Antibody (G-6) Specifications

Alternate Product Name: PTEN

Product Clone Name: G-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-403

Epitope Target: PTEN

Epitope Species: human

Product Reactivity/Detection: PTEN

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for PTEN Antibody (G-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred PTEN antibody is PTEN Antibody (A2B1): sc-7974.