PTEN Antibody (B-1): sc-133197

PTEN Antibody (B-1) is a mouse monoclonal IgG2b kappa light chain antibody engineered to recognize the full-length PTEN protein, also known as phosphatase and tensin homolog, MMAC1, or TEP1. PTEN monoclonal antibody (B-1) targets amino acids 1-403 of human PTEN and is validated for use in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA) applications across mouse, rat, and human species. PTEN is a pivotal tumor suppressor protein that plays a crucial role in regulating cell growth, proliferation, and survival by dephosphorylating phosphatidylinositol (3,4,5)-trisphosphate, thereby antagonizing the PI3K/AKT signaling pathway. The proper functioning of PTEN is essential for maintaining cellular homeostasis and preventing uncontrolled cell division, which is why loss or mutation is frequently associated with various cancers, including glioblastomas, breast, kidney, and prostate cancers. PTEN interacts with several key proteins, such as p53, which enhances tumor-suppressive functions, and PDZ domain-containing proteins like MAGI-2 and MAGI-3, which help regulate stability and localization within the cell. Additionally, PTEN forms complexes with proteins like AKT and SHC, modulating downstream signaling pathways that influence cell migration and apoptosis. Anti-PTEN antibody (B-1) enables researchers to effectively investigate these protein-protein interactions and elucidate the molecular mechanisms by which PTEN exerts tumor suppressor activities. PTEN (B-1) antibody serves as an invaluable tool for studies focused on cancer biology, enabling detailed analysis of PTEN-related pathways and the development of targeted therapeutic strategies aimed at restoring function in cancerous cells.

The preferred PTEN antibody is PTEN Antibody (A2B1): sc-7974.