PTEN Antibody (A2B1): sc-7974

PTEN Antibody (A2B1) is a mouse monoclonal IgG1 kappa light chain antibody specifically designed to detect PTEN, also known as phosphatase and tensin homolog, MMAC1, or TEP1. PTEN mouse monoclonal antibody (A2B1) targets the C-terminal epitope of PTEN, recognizing amino acids 388-400, and is effective across multiple species including mouse, rat, and human. PTEN (A2B1) antibody functions as a lipid and protein phosphatase, playing a significant role in regulating cellular processes such as growth, proliferation, and survival by antagonizing the PI3K/AKT signaling pathway. The loss or mutation of PTEN is frequently observed in various cancers, including glioblastomas, breast, kidney, and prostate cancers, highlighting its importance in maintaining normal cellular function and preventing tumorigenesis. PTEN monoclonal antibody (A2B1) is versatile in its applications, suitable for western blotting, immunoprecipitation, immunofluorescence, immunohistochemistry (including paraffin-embedded samples), and ELISA assays, making anti-PTEN (A2B1) antibody an essential tool for cancer research and the study of PTEN-related pathways. Additionally, PTEN (A2B1) monoclonal antibody is available in multiple conjugated forms, such as agarose, HRP, PE, FITC, and various Alexa Fluor® conjugates, providing flexibility for diverse experimental requirements. By enabling accurate detection and analysis, PTEN mouse monoclonal antibody (A2B1) facilitates advancements in understanding the molecular mechanisms underlying cancer development and progression, as well as the potential for developing targeted therapies.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

PTEN Antibody (A2B1) References:

1. PTEN.  |  Worby, CA. and Dixon, JE. 2014. Annu Rev Biochem. 83: 641-69. PMID: 24905788
2. Clonal genomic alterations in glioma malignancy stages.  |  James, CD., et al. 1988. Cancer Res. 48: 5546-51. PMID: 2901288
3. PTEN: Tumor Suppressor and Metabolic Regulator.  |  Chen, CY., et al. 2018. Front Endocrinol (Lausanne). 9: 338. PMID: 30038596
4. Mechanisms of PTEN loss in cancer: It's all about diversity.  |  Álvarez-Garcia, V., et al. 2019. Semin Cancer Biol. 59: 66-79. PMID: 30738865
5. PTEN in the Stroma.  |  Thies, KA., et al. 2019. Cold Spring Harb Perspect Med. 9: PMID: 31427286
6. PTEN in Chromatin Remodeling.  |  Yang, J. and Yin, Y. 2020. Cold Spring Harb Perspect Med. 10: PMID: 31570373
7. Specific chromosomal abnormalities in malignant human gliomas.  |  Bigner, SH., et al. 1988. Cancer Res. 48: 405-11. PMID: 3335011
8. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.  |  Li, J., et al. 1997. Science. 275: 1943-7. PMID: 9072974
9. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers.  |  Steck, PA., et al. 1997. Nat Genet. 15: 356-62. PMID: 9090379
10. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome.  |  Liaw, D., et al. 1997. Nat Genet. 16: 64-7. PMID: 9140396
11. Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.  |  Nelen, MR., et al. 1997. Hum Mol Genet. 6: 1383-7. PMID: 9259288
12. Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain.  |  Furnari, FB., et al. 1997. Proc Natl Acad Sci U S A. 94: 12479-84. PMID: 9356475

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PTEN Antibody (A2B1) has 545 citations in a variety of scientific publications.

Primary antibodies like Anti-PTEN Antibody (A2B1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PTEN Antibody (A2B1) Specifications

Alternate Product Name: PTEN

Product Clone Name: A2B1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 388-400

Epitope Target: PTEN

Epitope Species: human

Product Reactivity/Detection: PTEN

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 545 citations in various scientific publications

Available Conjugates/Forms for PTEN Antibody (A2B1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin