PTEN Antibody (A2B1): sc-7974
- PTEN Antibody (A2B1) is a mouse monoclonal IgG1 κ PTEN antibody, cited in 545 publications, provided at 200 µg/ml
- raised against amino acids 388-400 mapping at the C-terminus of PTEN of human origin
- PTEN Antibody (A2B1) is recommended for detection of PTEN of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-PTEN Antibody (A2B1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PTEN Antibody (A2B1) for WB and IHC(P) applications. These reagents are now offered in bundles with PTEN Antibody (A2B1) (see ordering information below).
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PTEN Antibody (A2B1) is a mouse monoclonal IgG1 kappa light chain antibody specifically designed to detect PTEN, also known as phosphatase and tensin homolog, MMAC1, or TEP1. PTEN mouse monoclonal antibody (A2B1) targets the C-terminal epitope of PTEN, recognizing amino acids 388-400, and is effective across multiple species including mouse, rat, and human. PTEN (A2B1) antibody functions as a lipid and protein phosphatase, playing a significant role in regulating cellular processes such as growth, proliferation, and survival by antagonizing the PI3K/AKT signaling pathway. The loss or mutation of PTEN is frequently observed in various cancers, including glioblastomas, breast, kidney, and prostate cancers, highlighting its importance in maintaining normal cellular function and preventing tumorigenesis. PTEN monoclonal antibody (A2B1) is versatile in its applications, suitable for western blotting, immunoprecipitation, immunofluorescence, immunohistochemistry (including paraffin-embedded samples), and ELISA assays, making anti-PTEN (A2B1) antibody an essential tool for cancer research and the study of PTEN-related pathways. Additionally, PTEN (A2B1) monoclonal antibody is available in multiple conjugated forms, such as agarose, HRP, PE, FITC, and various Alexa Fluor® conjugates, providing flexibility for diverse experimental requirements. By enabling accurate detection and analysis, PTEN mouse monoclonal antibody (A2B1) facilitates advancements in understanding the molecular mechanisms underlying cancer development and progression, as well as the potential for developing targeted therapies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PTEN Antibody (A2B1) References:
- PTEN. | Worby, CA. and Dixon, JE. 2014. Annu Rev Biochem. 83: 641-69. PMID: 24905788
- Clonal genomic alterations in glioma malignancy stages. | James, CD., et al. 1988. Cancer Res. 48: 5546-51. PMID: 2901288
- PTEN: Tumor Suppressor and Metabolic Regulator. | Chen, CY., et al. 2018. Front Endocrinol (Lausanne). 9: 338. PMID: 30038596
- Mechanisms of PTEN loss in cancer: It's all about diversity. | Álvarez-Garcia, V., et al. 2019. Semin Cancer Biol. 59: 66-79. PMID: 30738865
- PTEN in the Stroma. | Thies, KA., et al. 2019. Cold Spring Harb Perspect Med. 9: PMID: 31427286
- PTEN in Chromatin Remodeling. | Yang, J. and Yin, Y. 2020. Cold Spring Harb Perspect Med. 10: PMID: 31570373
- Specific chromosomal abnormalities in malignant human gliomas. | Bigner, SH., et al. 1988. Cancer Res. 48: 405-11. PMID: 3335011
- PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. | Li, J., et al. 1997. Science. 275: 1943-7. PMID: 9072974
- Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. | Steck, PA., et al. 1997. Nat Genet. 15: 356-62. PMID: 9090379
- Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. | Liaw, D., et al. 1997. Nat Genet. 16: 64-7. PMID: 9140396
- Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease. | Nelen, MR., et al. 1997. Hum Mol Genet. 6: 1383-7. PMID: 9259288
- Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. | Furnari, FB., et al. 1997. Proc Natl Acad Sci U S A. 94: 12479-84. PMID: 9356475
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTEN Antibody (A2B1) | sc-7974 | 200 µg/ml | $322.00 | |||
PTEN Antibody (A2B1): m-IgG Fc BP-HRP Bundle | sc-528194 | 200 µg Ab; 10 µg BP | $361.00 | |||
PTEN Antibody (A2B1): m-IgGκ BP-HRP Bundle | sc-520516 | 200 µg Ab, 40 µg BP | $361.00 | |||
PTEN Antibody (A2B1): m-IgG1 BP-HRP Bundle | sc-542809 | 200 µg Ab; 20 µg BP | $361.00 | |||
PTEN Antibody (A2B1) AC | sc-7974 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PTEN Antibody (A2B1) HRP | sc-7974 HRP | 200 µg/ml | $322.00 | |||
PTEN Antibody (A2B1) FITC | sc-7974 FITC | 200 µg/ml | $336.00 | |||
PTEN Antibody (A2B1) PE | sc-7974 PE | 200 µg/ml | $349.00 | |||
PTEN Antibody (A2B1) Alexa Fluor® 488 | sc-7974 AF488 | 200 µg/ml | $364.00 | |||
PTEN Antibody (A2B1) Alexa Fluor® 546 | sc-7974 AF546 | 200 µg/ml | $364.00 | |||
PTEN Antibody (A2B1) Alexa Fluor® 594 | sc-7974 AF594 | 200 µg/ml | $364.00 | |||
PTEN Antibody (A2B1) Alexa Fluor® 647 | sc-7974 AF647 | 200 µg/ml | $364.00 | |||
PTEN Antibody (A2B1) Alexa Fluor® 680 | sc-7974 AF680 | 200 µg/ml | $364.00 | |||
PTEN Antibody (A2B1) Alexa Fluor® 790 | sc-7974 AF790 | 200 µg/ml | $364.00 |